我的台灣, 看見心靈的故鄉 =2009林磐聳藝術與設計展

2004아테네 올림픽대회출전 한국레슬링 대표선수의 무산소성 운동능력 및 등속성 근력

Nearly a century after Einstein first predicted the existence of gravitational waves, a global network of Earth-based gravitational wave observatories1, 2, 3, 4 is seeking to directly detect this faint radiation using precision laser interferometry. Photon shot noise, due to the quantum nature of light, imposes a fundamental limit on the attometre-level sensitivity of the kilometre-scale Michelson interferometers deployed for this task. Here, we inject squeezed states to improve the performance of one of the detectors of the Laser Interferometer Gravitational-Wave Observatory (LIGO) beyond the quantum noise limit, most notably in the frequency region down to 150 Hz, critically important for several astrophysical sources, with no deterioration of performance observed at any frequency. With the injection of squeezed states, this LIGO detector demonstrated the best broadband sensitivity to gravitational waves ever achieved, with important implications for observing the gravitational-wave Universe with unprecedented sensitivity.

Enhanced sensitivity of the LIGO gravitational wave detector by using squeezed states of light

2003-예방원년, 소아과 의사의 역할

Development of fluorescent sensing of anions under excited-state intermolecular proton transfer signaling mechanism

The recent appearance of COVID-19 virus has created a global crisis due to unavailability of any vaccine or drug that can effectively and deterministically work against it. Naturally, different pos...

In silico investigation of phytoconstituents from Indian medicinal herb ' Tinospora cordifolia (giloy)' against SARS-CoV-2 (COVID-19) by molecular dynamics approach.

Excited state proton transfer in 2-hydroxy 1-naphthaldehyde (HNL) has been reported on the basis of steady state absorption and emission, time-resolved emission, and semiempirical quantum chemical calculations. The existence of open and closed ring conformers in the ground state gives rise to different emissions upon excitation in hydroxylic and hydrocarbon solvents, respectively. Formation of the ground state HNL ion in open conformer was observed with addition of base. Excitation of the closed conformer leads to intramolecular proton transfer across the preexisting intramolecular hydrogen bond to give excited zwitterion in hydrocarbon solvents. On excitation of the open ring conformer in hydroxylic solvents, emission from the neutral excited state could be observed for the first time apart from the emission of ionic intermolecular proton transfer species. An increase or decrease in pH results in enhancement or a decrease of emission from the ionic conformer with parallel dwindling or intensification of ...

Excited State Prototropic Activities in 2-Hydroxy 1-Naphthaldehyde

Northeastern Hill Region (NHR) of India, by virtue of its strategic setting in the frail landscape of Eastern Himalaya falls in the most vulnerable zones of abrupt climate change. Despite this, little attention has been given to understand climate change impact implications. In the present study, long time (1983-2010) weather variables have been analyzed to detect trend changes using non-parametric Mann Kendall test in mid altitude of Meghalaya (Umiam: 25 0 41 / N latitude, 91 0 55 / E longitude, 1010m msl). Results revealed that total annual rainfall trend increased non-significantly at the rate of 3.72mm year -1 . Contribution of monsoon months (JJAS) declined marginally at the rate of 1.70 mm while pre (MAM) and post- monsoon (ONDJF) months increased non-significantly at an annual rate of 3.18 mm and 1.16 mm, respectively. Probability analysis showed a high frequency of anomalies (p>0.6) of either deficit or excess in occurrence of normal monsoon rainfall. Number of rainy days and extreme rainfall events (RX1 day maximum>100mm) exhibited a non-significant increasing trend @ 1.7 days and 1.9 days per decade, respectively. Maximum temperature reflected a linear, significant rising trend (+ 0.086 0 C year -1 ) while minimum temperature enumerated a non-significant decreasing trend (-0.011 0 C year -1 ). Mean temperature also manifested a significant rising trend at an annual rate of 0.031 0 C while annual evaporation loss significantly decreased (@ 5.75 mm year -1 ). Correlation studies affirmed that atmospheric evaporative demand was relatively more sensitive to changes in sunshine duration(r=+0.63) followed by wind speed (r=+0.41) and vapour pressure deficit (r= 0.11). Climatic water balance studies (rainfall and PET) reflected an increasing trend of water surplus during May to July (Z: +0.08 to 1.56) whereas a reverse trend (declining, Z: -0.56 to -0.87) was observed during post monsoon months (December to February).

Trend Analysis of Long Term Weather Variables in Mid Altitude Meghalaya, North-East India

The recent appearance of COVID-19 virus has created a global crisis due to unavailability of any vaccine or drug that can effectively and deterministically work against it. Naturally, different possibilities (including herbal medicines having known therapeutic significance) have been explored by the scientists. The systematic scientific study (beginning with in silico study) of herbal medicines in particular and any drug in general is now possible as the structural components (proteins) of COVID-19 are already characterized. The main protease of COVID-19 virus is $\rm{M^{pro}}$ or $\rm{3CL^{pro}}$ which is a key CoV enzyme and an attractive drug target as it plays a pivotal role in mediating viral replication and transcription. In the present study, $\rm{3CL^{pro}}$ is used to study drug:3CLpro interactions and thus to investigate whether all or any of the main chemical constituents of Tinospora cordifolia (e.g., berberine $\rm{(C_{20}H_{18}NO_{4})}$, $\beta$-sitosterol $\rm{(C_{29}H_{50}O)}$, choline $\rm{(C_{5}H_{14}NO)}$, tetrahydropalmatine $\rm{(C_{21}H_{25}NO_{4})}$ and octacosanol $\rm{(C_{28}H_{58}O))}$ can be used as an anti-viral drug against SARS-CoV-2. The in silico study performed using tools of network pharmacology, molecular docking including molecular dynamics have revealed that among all considered phytochemicals in Tinospora cordifolia, berberine can regulate $\rm{3CL^{pro}}$ protein's function due to its easy inhibition and thus can control viral replication. The selection of Tinospora cordifolia was motivated by the fact that the main constituents of it are known to be responsible for various antiviral activities and the treatment of jaundice, rheumatism, diabetes, etc.

In Silico Investigation of Phytoconstituents from Indian Medicinal Herb 'Tinospora cordifolia (Giloy)' against SARS-CoV-2 (COVID-19) by Molecular Dynamics Approach

Papia Chowdhury

Papers

In silico investigation of phytoconstituents from Indian medicinal herb ' Tinospora cordifolia (giloy)' against SARS-CoV-2 (COVID-19) by molecular dynamics approach.

Excited State Prototropic Activities in 2-Hydroxy 1-Naphthaldehyde

Trend Analysis of Long Term Weather Variables in Mid Altitude Meghalaya, North-East India

In Silico Investigation of Phytoconstituents from Indian Medicinal Herb 'Tinospora cordifolia (Giloy)' against SARS-CoV-2 (COVID-19) by Molecular Dynamics Approach

Role of hydrogen bonding in excited state intramolecular proton transfer of Indole-7-Carboxaldehyde: A theoretical and experimental study