Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: 
wherein M is N or CR 4 ; Q 1 and Q 2 are each independently selected from the group consisting of CO, SO, SO 2 , and C═NR 9 ; and each L, X, R 1 , R 2 , and R 3 are as defined herein.

Dipeptidyl peptidase inhibitors

Recent advances in synthetic applications of azadienes

A catalyst- and solvent-free selective approach to biologically important quinazolines and benzo[g]quinazoline

The reactions of 4-dialkylamino substituted 1,3-diazabuta-1,3-dienes 1 with butadienylketene 2, are shown to undergo [4 + 2] cycloadditions to yield 5-(buta-1′,3′-dienyl)pyrimidinone 4 and tandem [1,5]H and [1,5]SCH3 shifts are shown to accompany the [4 + 2] cycloaddition reactions of 4-dialkylamino-4-methylthio substituted 1,3-diazabuta-1,3-dienes 5 with 2. The regioselective reactions of N-arylamino-1,3-diazabuta-1,3-dienes 11 and 14 with butadienylketene 2 are reported to yield 5-(buta-1′,3′-dienyl)-2-dialkylaminopyrimidin-4(3H)-one 13
and a mixture of 5-(buta-1′,3′-dienyl)-2-methylthiopyrimidin-4(3H)-one 17, 2-methylthio-5-[1′-(N-phenylamino)but-2′-enyl]pyrimidin-4(3H)-one 19 and 2-methylthio-5-[3′-(N-phenylamino)but-1′-enyl]pyrimidin-4(3H)-one 20, respectively. Tandem [1,5]H, [1,3]NHPh and [1,5]NHPh shifts are involved in the formation of pyrimidinones 19 and 20. The Diels–Alder reactions of the 5-dienylpyrimidinones with dimethyl acetylenedicarboxylate (DMAD) and 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) yielded corresponding cycloadducts.

Tandem sigmatropic shifts in [4 + 2] cycloaddition reactions of 1,3-diazabuta-1,3-dienes with butadienylketene: synthesis of pyrimidinone derivatives

Pharmaceutical compositions comprising 2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-4-fluoro-benzonitrile and pharmaceutically acceptable salts thereof are provided as well as kits and articles of manufacture comprising the pharmaceutical compositions as well as methods of using the pharmaceutical compositions.

Administration of dipeptidyl peptidase inhibitors

Regioselective [4+2] cycloaddition versus nucleophilic reactions of N-arylamino substituted 1,3-diaza-1,3-butadienes with ketenes: Synthesis of pyrimidinone and fused pyrimidinone derivatives. Part II

Synthesis and regioselective [4+2] cycloaddition/nucleophilic reactions of N-arylamino-1:3-diaza-1:3-butadienes with ketenes and accompanying rearrangements

N-Arylamino-1:3-diaza-1:3-butadienes 4 are shown to undergo regioselective reactions with phenyl- and chloroketenes resulting in high yields of 3-aryl-2-methylthio6-phenyl-4(3H)-pyrimidinones 7 . Similar reactions with bromo- and iodoketenes, resulted, via aziridinium intermediates 12 , in good yields of 3-aryl-S-(N-arylamino)-2-methylthio-6-phenyl4(3H)-pyrimidinones 13 , The mechanistic aspects of cycloadditions and semi-empirical AM1 calculations for these diazabutadienes are also reported.

Synthesis and Regioselective (4 + 2) Cycloaddition/Nucleophilic Reactions of N‐Arylamino‐1,3‐diaza‐1,3‐butadienes with Ketenes and Accompanying Rearrangements.

Convenient one pot synthesis of 2-anfinothiazole derivatives involving reactions of 1,3-diazabuta-1,3-dienes with thioglycolic acid, ethyl bromoacetate are reported.

/pdf/facile-one-pot-synthesis-of-2-aminothiazoles-from-1-3-oj969ekplb.pdf

Facile one-pot synthesis of 2-aminothiazoles from 1 ,3-diazabuta-4-methylthio-1,3-dienes

Convenient one pot synthesis of 2-anfinothiazole derivatives involving reactions of 1,3-diazabuta-1,3-dienes with thioglycolic acid, ethyl bromoacetate are reported

Paramita D. Dey

Papers

Regioselective [4+2] cycloaddition versus nucleophilic reactions of N-arylamino substituted 1,3-diaza-1,3-butadienes with ketenes: Synthesis of pyrimidinone and fused pyrimidinone derivatives. Part II

Synthesis and regioselective [4+2] cycloaddition/nucleophilic reactions of N-arylamino-1:3-diaza-1:3-butadienes with ketenes and accompanying rearrangements

Synthesis and Regioselective (4 + 2) Cycloaddition/Nucleophilic Reactions of N‐Arylamino‐1,3‐diaza‐1,3‐butadienes with Ketenes and Accompanying Rearrangements.

Facile one-pot synthesis of 2-aminothiazoles from 1 ,3-diazabuta-4-methylthio-1,3-dienes

Facile One-Pot Synthesis of 2-Aminothiazoles from 1,3-Diazabuta-4-methylthio-1,3-dienes.