Journal ArticleDOI
Regioselective [4+2] cycloaddition versus nucleophilic reactions of N-arylamino substituted 1,3-diaza-1,3-butadienes with ketenes: Synthesis of pyrimidinone and fused pyrimidinone derivatives. Part II
TLDR
In this paper, a novel synthetic method for 3-aryl-6-phenyl-2-methylthio/secondaryamino substituted-4(3 H )-pyrimidinones 5 and 9 by the reactions of N -arylamino substituted 1,3-diaza-1, 3-butadienes 1 and 6 with phenyl-, vinyl- and isopropenylketenes is explored.About:
This article is published in Tetrahedron.The article was published on 1997-10-06. It has received 31 citations till now. The article focuses on the topics: Pyrimidinones & Cycloaddition.read more
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Patent
Dipeptidyl peptidase inhibitors
Jun Feng,II Stephen L. Escondido Gwaltney,Stephen W. Kaldor,Jeffrey A. Stafford,Michael B. Wallace,Zhiyuan Zhang +5 more
TL;DR: In this paper, pharmaceuticals, kits and methods for use with DPP-IV and other S9 proteases that comprise a compound comprising of CO, SO, SO 2, and C═NR 9 are described.
Journal ArticleDOI
Recent advances in synthetic applications of azadienes
Journal ArticleDOI
A catalyst- and solvent-free selective approach to biologically important quinazolines and benzo[g]quinazoline
TL;DR: In this paper, a solvent-free and catalyst-free approach for the selective synthesis of quinazolines and benzo[g] quinzolines has been developed using conventional microwave oven with excellent yields and reproducibilty.
Journal ArticleDOI
Tandem sigmatropic shifts in [4 + 2] cycloaddition reactions of 1,3-diazabuta-1,3-dienes with butadienylketene: synthesis of pyrimidinone derivatives
TL;DR: In this paper, the reaction of 4-dialkylamino-4-methylthio substituted 1,3-diazabuta-1, 3-dienes with butadienylketene 2 with 2.
Patent
Administration of dipeptidyl peptidase inhibitors
TL;DR: In this article, pharmacological compositions comprising 2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3, 4-fluoro-benzonitrile and pharmaceutically acceptable salts thereof are provided.
References
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Journal ArticleDOI
Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model
TL;DR: In this paper, a new parametric quantum mechanical molecular model, AM1 (Austin Model l), based on the NDDO approximation, is described, in which the major weaknesses of MNDO, in particular failure to reproduce hydrogen bonds, have been overcome without any increase in computing time.
Book
Hetero Diels-Alder methodology in organic synthesis
Dale L. Boger,Steven M. Weinreb +1 more
TL;DR: In this article, N-Sulfinyl Compounds and Sulfur Diimides are classified into three classes: Nitroso and Thionitroso Dienophiles.
Journal ArticleDOI
Diels-Alder reactions of azadienes
TL;DR: On etudie successivement les systemes aza-1 butadiene, triazabutadiene and diaza- 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22,
Journal ArticleDOI
Oligodeoxynucleotides containing C-5 propyne analogs of 2'-deoxyuridine and 2'-deoxycytidine
TL;DR: Oligodeoxynucleotides (ODN) containing 5-(1-propynyl)-2′-deoxyuridine and 5-( 1-propnymyr)-2'deoxycytidine significantly enhance double-helix formation with single strand RNA.
Journal ArticleDOI
Studies on lactams. Part 84. .beta.-Lactams via .alpha.,.beta.-unsaturated acid chlorides: intermediates for carbapenem antibiotics
TL;DR: Stereocontrolled synthesis of α-vinyl β-lactams and their transformation to convenient intermediates for PS-5, PS-6, asparenomycin, and thienamycin are described.