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Parissa Keshavarzian
Researcher at University of California, San Diego
Publications - 2
Citations - 196
Parissa Keshavarzian is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 2, co-authored 2 publications receiving 122 citations.
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Journal ArticleDOI
Novel Third-Generation EGFR Tyrosine Kinase Inhibitors and Strategies to Overcome Therapeutic Resistance in Lung Cancer
Ayesha Murtuza,Ajaz Bulbul,John Paul Shen,Parissa Keshavarzian,Brian Woodward,Fernando J. Lopez-Diaz,Scott M. Lippman,Hatim Husain +7 more
TL;DR: The compound osimertinib is a third-generation tyrosine kinase inhibitor, which was granted full FDA approval in March 2017 based on targeting EGFR T790M resistance and has received additional FDA approval as first-line therapy with improvement in progression-free survival by suppressing the activating mutation and preventing the rise of the dominant resistance clone.
Journal ArticleDOI
Early Noninvasive Detection of Response to Targeted Therapy in Non–Small Cell Lung Cancer
Jillian Phallen,Alessandro Leal,Brian Woodward,Patrick M. Forde,Jarushka Naidoo,Kristen A. Marrone,Julie R. Brahmer,Jacob Fiksel,Jamie E. Medina,Stephen Cristiano,Doreen N. Palsgrove,Christopher D. Gocke,Daniel C. Bruhm,Parissa Keshavarzian,Vilmos Adleff,Elizabeth Weihe,Valsamo Anagnostou,Robert B. Scharpf,Victor E. Velculescu,Hatim Husain +19 more
TL;DR: An ultrasensitive measure of cell-free tumor load is developed using targeted and whole-genome sequencing approaches to assess responses to tyrosine kinase inhibitors in patients with advanced lung cancer and serves an unmet clinical need for real-time, noninvasive detection of tumor response to targeted therapies before radiographic assessment.