P
Parvez Alam
Researcher at Aligarh Muslim University
Publications - 54
Citations - 2830
Parvez Alam is an academic researcher from Aligarh Muslim University. The author has contributed to research in topics: Human serum albumin & Amyloid. The author has an hindex of 31, co-authored 49 publications receiving 2358 citations.
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Journal ArticleDOI
Elucidating the interaction of limonene with bovine serum albumin: a multi-technique approach
Sumit Kumar Chaturvedi,Ejaz Ahmad,Javed Masood Khan,Parvez Alam,Mohd Ishtikhar,Rizwan Hasan Khan +5 more
TL;DR: The present study will be helpful in understanding the binding mechanism of limonene and associated stability and conformational changes.
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Vitamin k3 inhibits protein aggregation: Implication in the treatment of amyloid diseases
Parvez Alam,Sumit Kumar Chaturvedi,Mohammad Khursheed Siddiqi,Ravi Kant Rajpoot,Mohd Rehan Ajmal,Masihuz Zaman,Rizwan Hasan Khan +6 more
TL;DR: It is demonstrated that vitamin k3 significantly inhibits fibril formation as well as the inhibitory effect is dose dependent manner, paving the way for discovery of other small molecules that may exert similar effect against amyloid formation and its associated neurodegenerative diseases.
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Biophysical and molecular docking insight into the interaction of cytosine β-D Arabinofuranoside with Human serum albumin
Parvez Alam,Sumit Kumar Chaturvedi,Tamanna Anwar,Mohammad Khursheed Siddiqi,Mohd Rehan Ajmal,Gamal Badr,Mohamed H. Mahmoud,Rizwan Hasan Khan +7 more
TL;DR: This study will be helpful to understand the binding mechanism of cytosine β-D arabinofuranoside with HSA and associated alterations and help understand the topology of protein in absence and presence of drug.
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Protein aggregation: From background to inhibition strategies.
TL;DR: Better therapeutics could be developed by using cocktail of small molecule inhibitors for the treatment of amyloid diseases by summarizes the background information on the protein folding, misfolding, cellular strategies against protein aggregation, factors affecting protein aggregation and mechanism of protein aggregation.
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Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity.
Parvez Alam,Ayesha Z. Beg,Mohammad Khursheed Siddiqi,Sumit Kumar Chaturvedi,Ravi Kant Rajpoot,Mohd Rehan Ajmal,Masihuz Zaman,Ali S. Abdelhameed,Rizwan Hasan Khan +8 more
TL;DR: It is demonstrated that ascorbic acid significantly inhibits the fibrillation of HI in a dose-dependent manner and Interestingly ascorBic acid destabilise the preformed amyloid fibrils and protects human neuroblastoma cell line (SH- SY5Y) against amyloids induced cytotoxicity.