Journal ArticleDOI
Biophysical and molecular docking insight into the interaction of cytosine β-D Arabinofuranoside with Human serum albumin
Parvez Alam,Sumit Kumar Chaturvedi,Tamanna Anwar,Mohammad Khursheed Siddiqi,Mohd Rehan Ajmal,Gamal Badr,Mohamed H. Mahmoud,Rizwan Hasan Khan +7 more
TLDR
This study will be helpful to understand the binding mechanism of cytosine β-D arabinofuranoside with HSA and associated alterations and help understand the topology of protein in absence and presence of drug.About:
This article is published in Journal of Luminescence.The article was published on 2015-08-01. It has received 130 citations till now. The article focuses on the topics: Isothermal titration calorimetry & Human serum albumin.read more
Citations
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Journal ArticleDOI
Inhibitory effect of phloretin on α-glucosidase: Kinetics, interaction mechanism and molecular docking.
TL;DR: The results indicated that phloretin is a strong α-glucosidase inhibitor, thus could be contribute to the improvement of diabetes mellitus.
Journal ArticleDOI
Vitamin k3 inhibits protein aggregation: Implication in the treatment of amyloid diseases
Parvez Alam,Sumit Kumar Chaturvedi,Mohammad Khursheed Siddiqi,Ravi Kant Rajpoot,Mohd Rehan Ajmal,Masihuz Zaman,Rizwan Hasan Khan +6 more
TL;DR: It is demonstrated that vitamin k3 significantly inhibits fibril formation as well as the inhibitory effect is dose dependent manner, paving the way for discovery of other small molecules that may exert similar effect against amyloid formation and its associated neurodegenerative diseases.
Journal ArticleDOI
Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity.
Parvez Alam,Ayesha Z. Beg,Mohammad Khursheed Siddiqi,Sumit Kumar Chaturvedi,Ravi Kant Rajpoot,Mohd Rehan Ajmal,Masihuz Zaman,Ali S. Abdelhameed,Rizwan Hasan Khan +8 more
TL;DR: It is demonstrated that ascorbic acid significantly inhibits the fibrillation of HI in a dose-dependent manner and Interestingly ascorBic acid destabilise the preformed amyloid fibrils and protects human neuroblastoma cell line (SH- SY5Y) against amyloids induced cytotoxicity.
Journal ArticleDOI
Protein misfolding and aggregation: Mechanism, factors and detection
TL;DR: The mechanism of amyloidogenesis in detail is described highlighting the major events including the association of native monomers into higher-ordered fibrillar structures and the factors influencing the microenvironment of protein, which in turn promotes amyloidsosis.
Journal ArticleDOI
Interplay of multiple interaction forces: Binding of tyrosine kinase inhibitor nintedanib with human serum albumin
TL;DR: Results demonstrate that fluorescence intensity of human serum albumin (HSA) gets quenched by NIB and quenching occurs in static manner and nintedanib increase the thermostability of HSA.
References
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Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Principles of fluorescence spectroscopy
TL;DR: This book describes the fundamental aspects of fluorescence, the biochemical applications of this methodology, and the instrumentation used in fluorescence spectroscopy.
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LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions
TL;DR: The LIGPLOT program automatically generates schematic 2-D representations of protein-ligand complexes from standard Protein Data Bank file input giving a simple and informative representation of the intermolecular interactions and their strengths, including hydrogen bonds, hydrophobic interactions and atom accessibilities.
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Thermodynamics of protein association reactions: forces contributing to stability
Philip D. Ross,S. Subramanian +1 more
TL;DR: On the basis of the thermochemical behavior of small molecule interactions, it is concluded that the strengthening of hydrogen bonds in the past decade, a complete thermodynamic description of the self-association of many proteins and their interactions is concluded.
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Structure of serum albumin.
Daniel C. Carter,Joseph X. Ho +1 more
TL;DR: This chapter provides an insight of the findings of past significant papers with the current knowledge of the recently determined high resolution X-ray structure of serum albumin and suggests that AFP may have a higher affinity for some unknown ligands important for fetal development.