P
Pascal Uehlinger
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 6
Citations - 277
Pascal Uehlinger is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Autofluorescence & Protoporphyrin IX. The author has an hindex of 4, co-authored 6 publications receiving 272 citations.
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Journal ArticleDOI
5-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells
Pascal Uehlinger,Matthieu Zellweger,Georges Wagnières,Lucienne Juillerat-Jeanneret,Hubert van den Bergh,Norbert Lange +5 more
TL;DR: The influence of parameters such as lipophilicity, concentration, time, and pH value on PpIX formation induced by ALA and its esters is investigated in human cell lines originating from the lung and bladder, finding ALA esters are found to be more lipophilic than the free acid.
Journal ArticleDOI
In vivo time-resolved spectroscopy of the human bronchial early cancer autofluorescence
Pascal Uehlinger,Tanja Gabrecht,Thomas M. Glanzmann,Jean-Pierre Ballini,Alexandre Radu,Snezana Andrejevic,Philippe Monnier,Georges Wagnières +7 more
TL;DR: The results suggest that the spectral contrast might be due to an enhanced blood concentration just below the epithelial layers of the lesion, and the measured lifetimes suggest that this fluorophore is elastin.
Journal ArticleDOI
On the Role of Iron and one of its Chelating Agents in the Production of Protoporphyrin IX Generated by 5-Aminolevulinic Acid and its Hexyl Ester Derivative Tested on an Epidermal Equivalent of Human Skin
TL;DR: Investigation of the modulation and pharmacokinetics of PPIX buildup after a 5 h incubation with ALA and one of its derivatives, the hexyl ester of ALA, on the human epidermal equivalent Epidex™ found a modified fluorescence spectrum, with the emergence of a peak at 590 nm, which is attributed to zinc protoporphyrin IX (Zn PPIX).
Proceedings ArticleDOI
Time-resolved autofluorescence spectroscopy of the bronchial mucosa for the detection of early cancer: clinical results
Thomas M. Glanzmann,Pascal Uehlinger,Jean-Pierre Ballini,Alexandre Radu,Tanja Gabrecht,Philippe Monnier,Hubert van den Bergh,Georges Wagnières +7 more
TL;DR: The fluorescence lifetime was assessed as a new contrast parameter between normal and malignant tissue and to explain the origin of a previously observed contrast in fluorescence intensity to find no indication for fluorescence quenching in the upper layers of the mucous membrane.
Proceedings ArticleDOI
Influence of the excitation wavelength on the Tumor-to-Healthy Contrast in Autofluorescence Bronchoscopy - A Comprehensive Study
Tanja Gabrecht,Pascal Uehlinger,Snezana Andrejevic,Pierre Grosjean,Alexandre Radu,Philippe Monnier,Bernd-Claus Weber,Hubert van den Bergh,Georges Wagnières +8 more
TL;DR: In this paper, the depth of the principal contrast mechanism within the bronchial tissue comparing a narrow band and broad band violet fluorescence excitation was found to have a non-superficial character.