P
Pascale Perry
Researcher at Imperial College London
Publications - 3
Citations - 1756
Pascale Perry is an academic researcher from Imperial College London. The author has contributed to research in topics: Chromatin & Cellular differentiation. The author has an hindex of 3, co-authored 3 publications receiving 1685 citations.
Papers
More filters
Journal ArticleDOI
Chromatin signatures of pluripotent cell lines
Véronique Azuara,Pascale Perry,Stephan Sauer,Mikhail Spivakov,Helle F. Jørgensen,Rosalind M. John,Rosalind M. John,Mina Gouti,Mina Gouti,Miguel Casanova,Gary Warnes,Matthias Merkenschlager,Amanda G. Fisher +12 more
TL;DR: It is shown that the epigenetic profile of pluripotent embryonic stem cells (ES) is distinct from that of embryonic carcinoma cells, haematopoietic stem cells and their differentiated progeny, and that lineage-specific genes are primed for expression in ES cells but are held in check by opposing chromatin modifications.
Journal ArticleDOI
Neural induction promotes large-scale chromatin reorganisation of the Mash1 locus
Ruth R. E. Williams,Véronique Azuara,Pascale Perry,Stephan Sauer,Maria Dvorkina,Helle F. Jørgensen,Jeffery Roix,Philip G. McQueen,Tom Misteli,Matthias Merkenschlager,Amanda G. Fisher +10 more
TL;DR: The results suggest that Mash1 is regulated by changes in chromatin structure and location and implicate the nuclear periphery as an important environment for maintaining the undifferentiated state of ES cells.
Journal ArticleDOI
A Dynamic Switch in the Replication Timing of Key Regulator Genes in Embryonic Stem Cells upon Neural Induction
Pascale Perry,Stephan Sauer,Nathalie Billon,William D. Richardson,Mikhail Spivakov,Gary Warnes,Frederick J. Livesey,Matthias Merkenschlager,Amanda G. Fisher,Véronique Azuara +9 more
TL;DR: The results show that loss of pluripotency (and lineage choice) is associated with extensive and predictable changes in the replication timing of key regulator genes.