Pasquale Scarcia

TL;DR: It is shown that UCP2 is a metabolite transporter that regulates substrate oxidation in mitochondria, and that it exports C4 metabolites from mitochondria to the cytosol in vivo and catalyzes an exchange of malate, oxaloacetate, and aspartate for phosphate.

TL;DR: A novel member of the AAC subfamily of mitochondrial metabolite transport proteins, termed AAC4, is identified and characterized, which exchanges ADP for ATP by an electrogenic antiport mechanism with high specificity and high sensitivity to carboxyatractyloside and bongkrekic acid.

TL;DR: Excessive Ca2+ levels are responsible for boosting AGC activity, mitochondrial metabolism and, to a more variable degree, oxidative stress in autistic brains, and their modulation could provide new preventive and therapeutic strategies.

TL;DR: The identification and functional reconstitution of Ant1p (Ypr128cp), a peroxisomal transporter in the yeast Saccharomyces cerevisiae, which has the characteristic sequence features of the mitochondrial carrier family is reported.

TL;DR: Interestingly, exposure to reactive oxygen species (ROS) scavengers dramatically increased the viability of the WB-12 transformant, suggesting that increased redox stress is involved in the pathogenesis of the disease and that anti-ROS therapy may be beneficial to patients.