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Patrícia C.F. Neves-Souza
Researcher at Oswaldo Cruz Foundation
Publications - 4
Citations - 330
Patrícia C.F. Neves-Souza is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Dengue virus & Dengue fever. The author has an hindex of 4, co-authored 4 publications receiving 312 citations.
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Journal ArticleDOI
Characterisation of lymphocyte response and cytokine patterns in patients with dengue fever.
Elzinandes Leal de Azeredo,Sonia M O Zagne,Marta A Santiago,A. C. M. S. Gouvêa,Adriana A. Santana,Patrícia C.F. Neves-Souza,Rita Maria Ribeiro Nogueira,Marize Pereira Miagostovich,Claire Fernandes Kubelka +8 more
TL;DR: During the acute phase of dengue infection subsets of T lymphocytes are depressed in terms of both rate and function and provide evidence that circulating pro-inflammatory cytokines, such as TNF-alpha, are important in the pathogenesis and severity of d Dengue.
Journal ArticleDOI
Differential regulation of toll-like receptor-2, toll-like receptor-4, CD16 and human leucocyte antigen-DR on peripheral blood monocytes during mild and severe dengue fever.
Elzinandes Leal de Azeredo,Patrícia C.F. Neves-Souza,Allan R. Alvarenga,Sônia Regina Nogueira Ignácio Reis,Amanda Torrentes-Carvalho,Sonia-Maris O Zagne,Rita Maria Ribeiro Nogueira,Luzia Maria de Oliveira-Pinto,Claire Fernandes Kubelka +8 more
TL;DR: It is shown, for the first time, phenotypic changes on peripheral monocytes that were characteristic of cell activation that were found after in vitro and in vivo DENV‐2 infection.
Journal ArticleDOI
Inducible Nitric Oxide Synthase (iNOS) Expression in Monocytes During Acute Dengue Fever in Patients and During in Vitro Infection
Patrícia C.F. Neves-Souza,Elzinandes Leal de Azeredo,Sonia M O Zagne,Rogério Valls-de-Souza,Sônia Regina Nogueira Ignácio Reis,Denise I S Cerqueira,Rita Maria Ribeiro Nogueira,Claire Fernandes Kubelka +7 more
TL;DR: This study is the first to reveal the activation ofDENV infected monocytes based on induction of iNOS both in vivo and in vitro, as well as the susceptibility of DENV-1 to a NO production.
Journal ArticleDOI
Comparison of dengue infection in human mononuclear leukocytes with mosquito C6/36 and mammalian Vero cells using flow cytometry to detect virus antigen
Farid Fo von Sydow,Marta A Santiago,Patrícia C.F. Neves-Souza,Denise I S Cerqueira,A. C. M. S. Gouvêa,Maryrose Fh Lavatori,Álvaro Luiz Bertho,Claire Fernandes Kubelka +7 more
TL;DR: Fluorescent activated cell sorter analysis turned out to be a reliable technique to quantify virus growth in traditional cell cultures of C6/36 as well as Vero cells and showed that human monocytes (CD14+) are preferred target cells for in vitro dengue infection among PBML.