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Patrícia Cavaco-Silva
Researcher at Instituto Superior de Ciências da Saúde Egas Moniz
Publications - 28
Citations - 855
Patrícia Cavaco-Silva is an academic researcher from Instituto Superior de Ciências da Saúde Egas Moniz. The author has contributed to research in topics: Antibiotics & Antibiotic resistance. The author has an hindex of 15, co-authored 26 publications receiving 676 citations. Previous affiliations of Patrícia Cavaco-Silva include University of Lisbon.
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Journal ArticleDOI
Clinical and bacteriological survey of diabetic foot infections in Lisbon
João J. Mendes,A. Marques-Costa,Cristina L. Vilela,José Neves,N. Candeias,Patrícia Cavaco-Silva,José Melo-Cristino +6 more
TL;DR: Prevalence and precocity of MDR organisms, namely MRSA, were high and were probably related to previous indiscriminate antibiotic use, so clinicians should avoid fluoroquinolones and more frequently consider the use of empirical anti-MRSA therapy.
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Wound healing potential of topical bacteriophage therapy on diabetic cutaneous wounds
João J. Mendes,Rodrigues Leandro Clara Isabel,Volker Côrte-Real Sofia,Raquel Barbosa,Patrícia Cavaco-Silva,José Melo-Cristino,Andrzej Górski,Miguel Garcia +7 more
TL;DR: The results suggest that topically administered bacteriophage treatment may be effective in resolving chronic infections, especially when applied in conjunction with wound debridement, and have important implications for the feasibility of using topical antimicrobial therapies to safely treat chronic infections in diabetes mellitus patients.
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Susceptibility patterns of Staphylococcus aureus biofilms in diabetic foot infections
Carla Mottola,Carina S. Matias,João J. Mendes,José Melo-Cristino,Luís Tavares,Patrícia Cavaco-Silva,Manuela Oliveira +6 more
TL;DR: It is demonstrated that very high concentrations of the most used antibiotics in treating diabetic foot infections (DFI) are required to inhibit S. aureus biofilms in vitro, which may explain why monotherapy with these agents frequently fails to eradicate biofilm infections.
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Klebsiella pneumoniae causing urinary tract infections in companion animals and humans: population structure, antimicrobial resistance and virulence genes
Cátia Marques,Juliana Perrone Bezerra de Menezes,Adriana Belas,Catarina Aboim,Patrícia Cavaco-Silva,Graça Trigueiro,Luis Telo da Gama,Constança Pomba +7 more
TL;DR: The population structure, antimicrobial resistance and virulence genes of Klebsiella spp.
Journal ArticleDOI
Novel chimerical endolysins with broad antimicrobial activity against methicillin-resistant Staphylococcus aureus.
Sofia Fernandes,Daniela Proença,Cátia Cantante,Filipa Silva,Rodrigues Leandro Clara Isabel,Ferreira Llorente Grancho Lourenco Sara,Catarina Milheiriço,Hermínia de Lencastre,Patrícia Cavaco-Silva,Madalena Pimentel,Carlos São-José +10 more
TL;DR: Fusion of endolysin domains of heterologous origin seems to be a suitable approach to design new potent endolysins with changed and/or extended lytic spectrum that are amenable to large-scale production.