H
Hermínia de Lencastre
Researcher at Rockefeller University
Publications - 196
Citations - 14794
Hermínia de Lencastre is an academic researcher from Rockefeller University. The author has contributed to research in topics: SCCmec & Methicillin-resistant Staphylococcus aureus. The author has an hindex of 62, co-authored 187 publications receiving 13297 citations. Previous affiliations of Hermínia de Lencastre include Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa & Universidade Nova de Lisboa.
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Journal ArticleDOI
Multiplex PCR Strategy for Rapid Identification of Structural Types and Variants of the mec Element in Methicillin-Resistant Staphylococcus aureus
TL;DR: The development, validation, and application of a multiplex PCR strategy that allows quick presumptive characterization of the mec element types based on the structural features that were shown to be typical of mec elements carried by several MRSA clones are reported.
Journal ArticleDOI
Evolution of MRSA During Hospital Transmission and Intercontinental Spread
Simon R. Harris,Edward J. Feil,Matthew T. G. Holden,Michael A. Quail,Emma K. Nickerson,Emma K. Nickerson,Narisara Chantratita,Susana Gardete,Susana Gardete,Ana Tavares,Nicholas P. J. Day,Nicholas P. J. Day,Jodi A. Lindsay,Jonathan D. Edgeworth,Jonathan D. Edgeworth,Hermínia de Lencastre,Hermínia de Lencastre,Julian Parkhill,Sharon J. Peacock,Sharon J. Peacock,Stephen D. Bentley +20 more
TL;DR: A high-throughput genomics approach is used to show that isolates of methicillin-resistant Staphylococcus aureus are precisely differentiated into a global geographic structure and suggest that intercontinental transmission has occurred for nearly four decades.
Journal ArticleDOI
Methicillin-resistant Staphylococcus aureus.
Andie S Lee,Andie S Lee,Hermínia de Lencastre,Hermínia de Lencastre,Javier Garau,Jan Kluytmans,Surbhi Malhotra-Kumar,Andreas Peschel,Stéphan Juergen Harbarth +8 more
TL;DR: The success of MRSA is a consequence of the extensive arsenal of virulence factors produced by S. aureus combined with β-lactam resistance and, for most clones, resistance to other antibiotic classes as discussed by the authors.
Journal ArticleDOI
Secrets of success of a human pathogen: molecular evolution of pandemic clones of meticillin-resistant staphylococcus aureus
TL;DR: It is suggested that the secrets of effectiveness of MRSA could be hidden in the unique genetic background of a surprisingly few lineages of S aureus particularly well able to cope with the contemporary clinical environment.
Journal ArticleDOI
Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing
Michael M. Mwangi,Shang Wei Wu,Yanjiao Zhou,Krzysztof Sieradzki,Hermínia de Lencastre,Paul G. Richardson,David Bruce,Edward M. Rubin,Eugene W. Myers,Eric D. Siggia,Alexander Tomasz +10 more
TL;DR: The power of whole-genome sequencing is applied to identify steps in the evolution of multidrug resistance in isogenic S. aureus isolates recovered periodically from the bloodstream of a patient undergoing chemotherapy with vancomycin and other antibiotics.