Patricia M. Watson

TL;DR: The observation that serum leptin is not related to energy expenditure rates suggests that leptin regulates body fat predominantly by altering eating behavior rather than calorigenesis, and there are important gender-based differences in the regulation and action of leptin in humans.

TL;DR: It is proposed that the beta 3-adrenergic receptor plays a central role in regulating the release of leptin from the adipocyte and that insulin-stimulated leptin release is blocked by simultaneous activation of cAMP-dependent protein kinase.

TL;DR: Test the hypotheses that uncoupling protein-1 (UCP1) expression is reduced in adipose tissue from ob/ob mice and is restored by treatment with exogenous leptin and suggest that decreased UCP1 expression in BAT and WAT of ob/OB mice is in part responsible for their increased metabolic efficiency and propensity to become obese.

TL;DR: It is established that norepinephrine is required for leptin to regulate its own expression in WAT and UCP1 expression in BAT and indicate that these effects are likely mediated through the centrally expressed long form of the leptin receptor.

TL;DR: It is demonstrated that the β3-AR is required for leptin-mediated regulation ofob mRNA expression in WAT, but is interchangeable with the β1/β2-ARs in mediating leptin's effect on UCP1 mRNAexpression in brown adipose tissue.