T
Thomas W. Gettys
Researcher at Pennington Biomedical Research Center
Publications - 141
Citations - 8294
Thomas W. Gettys is an academic researcher from Pennington Biomedical Research Center. The author has contributed to research in topics: Adipose tissue & White adipose tissue. The author has an hindex of 49, co-authored 139 publications receiving 7471 citations. Previous affiliations of Thomas W. Gettys include Howard Hughes Medical Institute & Medical University of South Carolina.
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The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure
TL;DR: The observation that serum leptin is not related to energy expenditure rates suggests that leptin regulates body fat predominantly by altering eating behavior rather than calorigenesis, and there are important gender-based differences in the regulation and action of leptin in humans.
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Multiplicity of mechanisms of serotonin receptor signal transduction
John R. Raymond,Yurii V. Mukhin,Andrew K. Gelasco,Andrew K. Gelasco,Justin H. Turner,Georgiann Collinsworth,Georgiann Collinsworth,Thomas W. Gettys,Jasjit S. Grewal,Maria N. Garnovskaya,Maria N. Garnovskaya +10 more
TL;DR: This review will focus on what is known about the signaling linkages of the G-protein-linked 5- HT receptors, and will highlight some fascinating new insights into 5-HT receptor signaling.
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FGF21 is an endocrine signal of protein restriction
Thomas Laeger,Tara M. Henagan,Diana C. Albarado,Leanne M. Redman,George A. Bray,Robert C. Noland,Heike Münzberg,Susan M. Hutson,Thomas W. Gettys,Michael W. Schwartz,Christopher D. Morrison +10 more
TL;DR: FGF21 represents an endocrine signal of protein restriction, which acts to coordinate metabolism and growth during periods of reduced protein intake and that FGF21 is required for behavioral and metabolic responses to protein restriction.
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The beta 3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes
TL;DR: It is proposed that the beta 3-adrenergic receptor plays a central role in regulating the release of leptin from the adipocyte and that insulin-stimulated leptin release is blocked by simultaneous activation of cAMP-dependent protein kinase.
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The recombinant 5-HT1A receptor: G protein coupling and signalling pathways.
TL;DR: The current review summarizes the most important studies of the recombinant 5‐HT1A receptor in the decade since the identificiation of its cDNA.