P
Patrick Kesteven
Researcher at Freeman Hospital
Publications - 42
Citations - 3919
Patrick Kesteven is an academic researcher from Freeman Hospital. The author has contributed to research in topics: Warfarin & Pulmonary embolism. The author has an hindex of 17, co-authored 41 publications receiving 3776 citations. Previous affiliations of Patrick Kesteven include Royal Victoria Infirmary & University of Newcastle.
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Journal ArticleDOI
Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
TL;DR: YP2C9 genotyping may identify a subgroup of patients who have difficulty at induction of warfarin therapy and are potentially at a higher risk of bleeding complications.
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The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: Proposal for a new dosing regimen
Elizabeth Sconce,Tayyaba Khan,Tayyaba Khan,Hilary Wynne,Hilary Wynne,Peter Avery,Peter Avery,Louise Monkhouse,Louise Monkhouse,Barry P. King,Barry P. King,Peter Wood,Peter Wood,Patrick Kesteven,Patrick Kesteven,Ann K. Daly,Ann K. Daly,Farhad Kamali,Farhad Kamali +18 more
TL;DR: The multivariate regression model including the variables of age, CYP2C9 and VKORC1 genotype, and height produced the best model for estimating warfarin dose (R2 = 55%).
Journal ArticleDOI
A Randomized Trial of Genotype-Guided Dosing of Warfarin
Munir Pirmohamed,Girvan Burnside,Niclas Eriksson,Andrea L. Jorgensen,Cheng Hock Toh,Toby Nicholson,Patrick Kesteven,Christina Christersson,Bengt Wahlström,Christina Stafberg,J. Eunice Zhang,Julian B. S. Leathart,Hugo Kohnke,Anke H. Maitland-van der Zee,Paula R Williamson,Ann K. Daly,Peter Avery,Farhad Kamali,Mia Wadelius,Abstr Act +19 more
TL;DR: Pharmacogenetic-based dosing was associated with a higher percentage of time in the therapeutic INR range than was standard dosing during the initiation of warfarin therapy.
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The value of education and self-monitoring in the management of warfarin therapy in older patients with unstable control of anticoagulation.
TL;DR: Quality‐of‐life measurements and health beliefs about warfarin were unchanged (apart from emotional role limitation) with education or education and self‐monitoring and is worthy of further study.
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Relation of lipid peroxides to macrovascular disease in type 2 diabetes.
TL;DR: The data support previous studies which demonstrate increased serum concentrations of TBARS in subjects with macrovascular disease but suggest that levels are similarly elevated in diabetic and non‐diabetic subjects.