P
Patrick Paulus
Researcher at Goethe University Frankfurt
Publications - 53
Citations - 2300
Patrick Paulus is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Transplantation & Angiogenesis. The author has an hindex of 25, co-authored 52 publications receiving 2015 citations. Previous affiliations of Patrick Paulus include Medical University of Vienna & University of Vienna.
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Journal ArticleDOI
Colony-Stimulating Factor-1 Blockade by Antisense Oligonucleotides and Small Interfering RNAs Suppresses Growth of Human Mammary Tumor Xenografts in Mice
Seyedhossein Aharinejad,Patrick Paulus,Mouldy Sioud,Michael Hofmann,Karin Zins,Romana Schäfer,E. Richard Stanley,Dietmar Abraham +7 more
TL;DR: It is demonstrated that CSF-1 and CSF -1 receptor are potential therapeutic targets for the treatment of mammary cancer and mouse survival significantly increased after CSf-1 blockade.
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Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts.
TL;DR: In combination with CMF, anti-CSF-1 Fab reversed chemoresistance of MCF-7 xenografts, suppressing tumor development by 56%, down-regulating expression of theChemoresistance genes breast cancer-related protein, multidrug resistance gene 1, and glucosylceramide synthase, and prolonging survival significantly.
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Novel aspects of fibrin(ogen) fragments during inflammation.
Carla Jennewein,Nguyen Tran,Patrick Paulus,Peter Ellinghaus,Johannes A. Eble,Kai Zacharowski +5 more
TL;DR: The state-of-the-art in inflammatory modulation by fibrin(ogen) andfibrin fragments is summarized, however, further research is required to gain better understanding of the entire role fibr in fragments play during inflammation and, possibly, disease development.
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Biomarkers of endothelial dysfunction: can they help us deciphering systemic inflammation and sepsis?
TL;DR: The endothelial integrity, as mechanical barrier against microorganisms and as natural “anticoagulant”, is crucial for physiologic organ function and biomarkers reflecting this special compartment may help in the early detection of systemic inflammation and its complications.
Journal Article
Colony-stimulating factor-1 antisense treatment suppresses growth of human tumor xenografts in mice.
Seyedhossein Aharinejad,Dietmar Abraham,Patrick Paulus,Hojatollah Abri,Michael Hofmann,Karl Grossschmidt,Romana Schäfer,E. Richard Stanley,Reinhold Hofbauer +8 more
TL;DR: The results suggest that human embryonic and colon cancer cells up-regulate host CSF-1 and MMP-2 expression, which could be a novel strategy in treatment of solid tumors.