K
Kai Zacharowski
Researcher at Goethe University Frankfurt
Publications - 513
Citations - 13221
Kai Zacharowski is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 51, co-authored 432 publications receiving 10241 citations. Previous affiliations of Kai Zacharowski include Bristol Royal Infirmary & Harefield Hospital.
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Journal ArticleDOI
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury.
Kianoush Kashani,Ali Al-Khafaji,Thomas Ardiles,Antonio Artigas,Sean M. Bagshaw,Max Bell,Azra Bihorac,Robert H. Birkhahn,Cynthia M. Cely,Lakhmir S. Chawla,Danielle Davison,Thorsten Feldkamp,Lui G. Forni,Michelle N. Gong,Kyle J. Gunnerson,Michael Haase,James Hackett,Patrick M. Honore,Eric Hoste,Olivier Joannes-Boyau,Michael Joannidis,Patrick K. Kim,Jay L. Koyner,Daniel T. Laskowitz,Matthew Lissauer,Gernot Marx,Peter A. McCullough,Scott Mullaney,Marlies Ostermann,Thomas Rimmelé,Nathan I. Shapiro,Andrew D. Shaw,Jing Shi,Amy M Sprague,Jean Louis Vincent,Christophe Vinsonneau,Ludwig Wagner,Michael G. Walker,R. Gentry Wilkerson,Kai Zacharowski,John A. Kellum +40 more
TL;DR: Two novel markers for AKI have been identified and validated in independent multicenter cohorts and are superior to existing markers, provide additional information over clinical variables and add mechanistic insight into AKI.
Journal ArticleDOI
Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: First update 2016.
Sibylle A. Kozek-Langenecker,Aamer B Ahmed,Arash Afshari,Pierre Albaladejo,Cesar Aldecoa,Guidrius Barauskas,Edoardo De Robertis,David Faraoni,Daniela Filipescu,Dietmar Fries,Thorsten Haas,Matthias Jacob,Marcus D. Lancé,Juan V.L. Pitarch,Susan Mallett,Jens Meier,Zsolt Molnár,Niels Rahe-Meyer,Charles Marc Samama,Jakob Stensballe,Philippe Van der Linden,Anne Wikkelsø,Patrick Wouters,Piet Wyffels,Kai Zacharowski +24 more
TL;DR: This update includes revisions to existing recommendations with respect to the wording, or changes in the grade of recommendation, and also the addition of new recommendations.
Journal ArticleDOI
Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients.
Christian F Weber,Klaus Görlinger,Dirk Meininger,Eva Herrmann,Tobias M. Bingold,Anton Moritz,Lawrence H. Cohn,Kai Zacharowski +7 more
TL;DR: Hemostatic therapy based on POC testing reduced patient exposure to allogenic blood products and provided significant benefits with respect to clinical outcomes.
Journal ArticleDOI
A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery
Patrick Meybohm,Berthold Bein,Oana Brosteanu,Jochen Cremer,Matthias Gruenewald,Christian Stoppe,Mark Coburn,G. Schaelte,Andreas Böning,Bernd Niemann,Jan P. Roesner,Frank Kletzin,U. Strouhal,Christian Reyher,Rita Laufenberg-Feldmann,Marion Ferner,I. F. Brandes,Martin Bauer,Sebastian Stehr,Andreas Kortgen,Maria Wittmann,Georg Baumgarten,Tanja Meyer-Treschan,Peter Kienbaum,Matthias Heringlake,Julika Schön,Michael Sander,Sascha Treskatsch,Thorsten Smul,Ewa Wolwender,Thomas F. Schilling,Georg Fuernau,Dirk Hasenclever,Kai Zacharowski +33 more
TL;DR: Upper-limb RIPC performed while patients were under propofol-induced anesthesia did not show a relevant benefit among patients undergoing elective cardiac surgery.
Journal ArticleDOI
Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat
Prabal K. Chatterjee,Salvatore Cuzzocrea,Paul A.J. Brown,Kai Zacharowski,Keith Nicol Stewart,Helder Mota-Filipe,Christoph Thiemermann +6 more
TL;DR: In vivo and in vitro, tempol significantly reduced the increase in urea, creatinine, gammaGT, AST, NAG, and FENa produced by renal ischemia/reperfusion, suggesting an improvement in both renal function and injury.