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Patrizia Luppi

Researcher at University of Pittsburgh

Publications -  41
Citations -  1989

Patrizia Luppi is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Inflammation & Type 1 diabetes. The author has an hindex of 23, co-authored 40 publications receiving 1853 citations. Previous affiliations of Patrizia Luppi include Walter and Eliza Hall Institute of Medical Research & Boston Children's Hospital.

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How immune mechanisms are affected by pregnancy

TL;DR: This work shows that during pregnancy maternal circulating immune cells undergo modifications in cell counts, phenotypes, functions and ability to produce soluble factors, such as cytokines, which plays a central role in the maternal adaptation to pregnancy.
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Monocytes are progressively activated in the circulation of pregnant women.

TL;DR: It is demonstrated that activation of maternal monocytes and granulocytes increases during pregnancy and support the idea that pregnancy results in an elevation of the innate immune system and suppression of the adaptive immune system.
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Monocytes of preeclamptic women spontaneously synthesize pro-inflammatory cytokines.

TL;DR: Flow cytometry results indicate that maternal circulating monocytes represent a source of inflammatory cytokines during preeclampsia.
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Normal pregnancy is associated with peripheral leukocyte activation.

TL;DR: This study was designed to analyse further the phenotype of subpopulations of peripheral blood leukocytes in normal pregnant women and found no significant differences in the percentage of different subpopulation of circulating leukocyte numbers.