Patrizia Porazzi

TL;DR: An overview of the current knowledge of thyroid gland origin and differentiation in the zebrafish is provided and the action of thyroid hormones and some aspects related to endocrine disruptors are considered.

TL;DR: Light is shed on an unsuspected crosstalk between hypoxia, Wnt and Notch signalling in GBM, and the potential to manipulate these microenvironmental signals to blunt GBM malignancy is suggested.

TL;DR: A new step in the zebrafish road to system biology is described, based on the use of transgenic biosensor animals expressing fluorescent proteins under the control of signaling pathway-responsive cis-elements.

TL;DR: These studies provide "proof of principle" that targeting CDK6 with PROTACs that inhibit its enzymatic activity and promote its degradation represents an effective strategy to exploit the "CDK6 dependence" of Ph+ ALL and, perhaps, of other hematological malignancies.

TL;DR: It is shown that oligodendrocyte-derived extracellular vesicles (Ol-EVs) contained multiple myelin-related antigens and tested their potential therapeutic effects; in multiple rodent models of experimental autoimmune encephalomyelitis (EAE), Ol-EV administration restored immune tolerance and reduced disease pathophysiology, suggesting that Ol- EVs might be an effective approach for MS.