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Patrocinio Molinero
Researcher at University of Seville
Publications - 44
Citations - 1077
Patrocinio Molinero is an academic researcher from University of Seville. The author has contributed to research in topics: Melatonin & Receptor. The author has an hindex of 18, co-authored 43 publications receiving 1009 citations. Previous affiliations of Patrocinio Molinero include Spanish National Research Council.
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Journal ArticleDOI
Melatonin biosynthesis in the thymus of humans and rats
Maria C. Naranjo,Juan M. Guerrero,Amalia Rubio,Patricia J. Lardone,Antonio Carrillo-Vico,M. P. Carrascosa-Salmoral,Silvia Jiménez-Jorge,M. V. Arellano,Santiago R. Leal-Noval,Miguel C. Leal,Eduardo Lissen,Patrocinio Molinero +11 more
TL;DR: It is demonstrated in humans and rats that thymus contains melatonin, expresses the mRNAs encoding N-acetyltransferase and hydroxyindol-O-methyltransferase, the two key enzymes of the melatonin synthesis, and has this biosynthetic machinery activated.
Journal ArticleDOI
Role of early cell-free DNA levels decrease as a predictive marker of fatal outcome after severe traumatic brain injury
Hada C. Macher,Juan José Egea-Guerrero,Jaume Revuelto-Rey,Elena Gordillo-Escobar,Judy Enamorado-Enamorado,Antonio Boza,Ana Rodríguez,Patrocinio Molinero,Juan M. Guerrero,J.M. Dominguez-Roldan,Francisco Murillo-Cabezas,Amalia Rubio +11 more
TL;DR: It is shown that severe TBI is associated with elevated cf-DNA levels and it is proposed that cf- DNA decrease during the first 24h may predict patient outcome and circulate cell-free DNA levels may be a possible biological marker aftersevere TBI.
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A novel interplay between membrane and nuclear melatonin receptors in human lymphocytes: significance in IL-2 production
TL;DR: A novel connection between melatonin membrane receptor signalling and RORα expression is shown, opening a new way to understand melatonin regulation in lymphocyte physiology.
Journal ArticleDOI
Circadian variations in the rat serum total antioxidant status: Correlation with melatonin levels
TL;DR: A nyctohemeral rhythm in serum total antioxidant status (TAS) in rats is shown which parallels the 24‐H melatonin cycle and results suggest that melatonin may be relevant in terms of participating in the antioxidative capacity of the rat serum.
Journal ArticleDOI
Evidence for melatonin synthesis in the rat brain during development
Silvia Jiménez-Jorge,Juan M. Guerrero,Antonio J. Jimenez-Caliani,Maria C. Naranjo,Patricia J. Lardone,Antonio Carrillo-Vico,Carmen Osuna,Patrocinio Molinero +7 more
TL;DR: The results demonstrate that, when the pineal is not yet producing melatonin, there is melatonin synthesis by the brain that could be used as protection from free radical damage and/or could exert some actions through MT1 receptors.