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Paul A. Armitage
Researcher at University of Sheffield
Publications - 117
Citations - 4558
Paul A. Armitage is an academic researcher from University of Sheffield. The author has contributed to research in topics: Stroke & Hyperintensity. The author has an hindex of 38, co-authored 112 publications receiving 3825 citations. Previous affiliations of Paul A. Armitage include Western General Hospital & Royal Hallamshire Hospital.
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Journal ArticleDOI
Lacunar stroke is associated with diffuse blood–brain barrier dysfunction
Joanna M. Wardlaw,Joanna M. Wardlaw,Fergus N. Doubal,Paul A. Armitage,Francesca M Chappell,Trevor Carpenter,Susana M. Maniega,Andrew J. Farrall,Cathie Sudlow,Martin Dennis,Baljean Dhillon +10 more
TL;DR: This data indicates that subtle generalized BBB leakiness in patients with lacunar stroke and control patients with cortical ischemic stroke could be explained by dysfunctional endothelium or blood–brain barrier leak, not just ischemia.
Journal ArticleDOI
A theoretical study of the effect of experimental noise on the measurement of anisotropy in diffusion imaging.
TL;DR: Although rotationally variant indices almost always underestimate the true diffusion anisotropy, they show only a small susceptibility to experimental noise and hence, are preferred to their rotationally invariant counterparts when the signal-to-noise ratio is small.
Journal ArticleDOI
Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study
Joanna M. Wardlaw,Stephen J. Makin,Maria del C. Valdés Hernández,Paul A. Armitage,Anna K. Heye,Francesca M Chappell,Susana Muñoz-Maniega,Eleni Sakka,Kirsten Shuler,Martin Dennis,Michael J. Thrippleton +10 more
TL;DR: This work has shown that subtle blood‐brain barrier leakage may be important in SVD‐induced brain damage and may help clarify the role of the EMT in small vessel disease.
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Comparison of 10 Different Magnetic Resonance Perfusion Imaging Processing Methods in Acute Ischemic Stroke Effect on Lesion Size, Proportion of Patients With Diffusion/Perfusion Mismatch, Clinical Scores, and Radiologic Outcomes
Ingrid Kane,Trevor Carpenter,Francesca Chappell,Carly S. Rivers,Paul A. Armitage,Peter Sandercock,Joanna M. Wardlaw +6 more
TL;DR: Perfusion lesion size differs markedly depending on the parameter calculated, and some parameters (mainly representing MTT measures) were correlation with clinical scores; others were correlated with final infarct size; and arrival time fitted was correlated with both.
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Blood-brain barrier permeability in Alzheimer's disease: a case-control MRI study.
TL;DR: MRI data suggest that BBB permeability is present even at an early stage of AD, and the extent of leakage was no greater than that of non-demented people of a similar age in this small sample, the temporal pattern differed, indicating different blood-brain-CSF compartmental kinetics.