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Paul A.J. Henricks
Researcher at Utrecht University
Publications - 121
Citations - 4702
Paul A.J. Henricks is an academic researcher from Utrecht University. The author has contributed to research in topics: Histamine & Cell adhesion molecule. The author has an hindex of 37, co-authored 115 publications receiving 4248 citations.
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Journal ArticleDOI
Reactive oxygen species as mediators in asthma.
TL;DR: With the use of inhibitors, transgenic animals and measurements of the release of ROS within the airways, it became clear that oxidative stress contributes to the initiation and worsening of inflammatory respiratory disorders.
Journal ArticleDOI
Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells
Meng Li,Betty C.A.M. van Esch,Gerry T. M. Wagenaar,Johan Garssen,Gert Folkerts,Paul A.J. Henricks +5 more
TL;DR: An overview is presented on the underlying mechanisms of the effects of SCFAs on both immune and endothelial cells, including HDACs, FFA2 and FFA3 receptors and GPR109A regulation of nuclear factor‐kappa B activation and mitogen‐activated protein kinase (MAPK) signaling pathways.
Journal ArticleDOI
Peroxynitrite: a two-faced metabolite of nitric oxide.
Richard B.R. Muijsers,Gert Folkerts,Paul A.J. Henricks,Gudarz Sadeghi-Hashjin,Frans P. Nijkamp +4 more
TL;DR: Whether peroxynitrite formation is a negative side effect of NO and superoxide release, or a functional characteristic is yet to be determined, and will be discussed in this review.
Journal ArticleDOI
1 alpha,25-dihydroxyvitamin D(3) potentiates the beneficial effects of allergen immunotherapy in a mouse model of allergic asthma : Role for IL-10 and TGF-beta
Yousef A. Taher,Betty C.A.M. van Esch,Gerard A. Hofman,Paul A.J. Henricks,Antoon J. M. van Oosterhout +4 more
TL;DR: It is demonstrated that 1,25(OH)2D3 potentiates the efficacy of immunotherapy and that the regulatory cytokines IL-10 and TGF-β play a crucial role in the effector phase of this mouse model.
Journal ArticleDOI
Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo.
Goudarz Sadeghi-Hashjin,Gert Folkerts,Paul A.J. Henricks,A. Verheyen,H. J. Van Der Linde,I. Van Ark,A. Coene,Frans P. Nijkamp +7 more
TL;DR: It is suggested that the generation of peroxynitrite from nitric oxide superoxide radicals during inflammatory processes induces epithelial damage, mediator release, and hence airway hyperresponsiveness, which may have clinical implications, because airway inflammation, epithelialdamage, and hyperresponsivity are characteristic features in patients suffering from asthma.