P
Paul D. Andrews
Researcher at University of Dundee
Publications - 34
Citations - 3495
Paul D. Andrews is an academic researcher from University of Dundee. The author has contributed to research in topics: Saccharomyces cerevisiae & Spindle checkpoint. The author has an hindex of 23, co-authored 34 publications receiving 3386 citations. Previous affiliations of Paul D. Andrews include Research Institute of Molecular Pathology.
Papers
More filters
Journal ArticleDOI
Aurora B Regulates MCAK at the Mitotic Centromere
Paul D. Andrews,Yulia Ovechkina,Nick Morrice,Michael Wagenbach,Karen Duncan,Linda Wordeman,Jason R. Swedlow +6 more
TL;DR: The results link Aurora B activity to MCAK function, with Aurora B regulating M CAK's activity and its localization at the centromere and kinetochore, and disruption of Aurora B function by expression of a kinase-dead mutant or RNAi prevented centromeric targeting of MCAk.
Journal ArticleDOI
Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.
Wolfgang Zachariae,Andrej Shevchenko,Andrej Shevchenko,Paul D. Andrews,Paul D. Andrews,Rafael Ciosk,Rafael Ciosk,Marta Galova,Marta Galova,Michael J. R. Stark,Michael J. R. Stark,Matthias Mann,Matthias Mann,Kim Nasmyth,Kim Nasmyth +14 more
TL;DR: The newly identified proteins Apc2p, Apc5p, and the RING-finger protein Apc11p are conserved from yeast to humans and are similar to the cullin Cdc53p, which is a subunit of the ubiquitin-protein ligase complex SCFCdc4 required for the initiation of DNA replication.
Journal ArticleDOI
The FIP3-Rab11 Protein Complex Regulates Recycling Endosome Targeting to the Cleavage Furrow during Late Cytokinesis
Gayle M. Wilson,Andrew B. Fielding,Glenn C. Simon,Xinzi Yu,Paul D. Andrews,Rebecca S. Hames,Andrew M. Frey,Andrew A. Peden,Gwyn W. Gould,Rytis Prekeris +9 more
TL;DR: It is proposed that the dynamic Rab11-FIP3 interaction controls the delivery, targeting, and fusion of recycling endosomes with furrow during late cytokinesis and abscission.
Journal ArticleDOI
Mitotic mechanics: the auroras come into view.
TL;DR: Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes and recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.
Journal ArticleDOI
Aurora kinases: shining lights on the therapeutic horizon?
TL;DR: The recent identification of novel binding partners and key downstream effectors, together with new small-molecule inhibitors that display efficacy against tumours, heralds an upsurge of interest in these critical kinases.