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Paul J. Colombo
Researcher at Tulane University
Publications - 34
Citations - 2019
Paul J. Colombo is an academic researcher from Tulane University. The author has contributed to research in topics: Hippocampus & CREB. The author has an hindex of 23, co-authored 33 publications receiving 1940 citations. Previous affiliations of Paul J. Colombo include University of California, Berkeley & University of North Carolina at Chapel Hill.
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Ageing: the cholinergic hypothesis of cognitive decline.
TL;DR: This review will address new information that has come from a recently developed method for selectively removing basal forebrain cholinergic neurons using an immunotoxin, with an emphasis on understanding the contribution of basal fore brain cholinergic neurons to age-related cognitive impairment.
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Cognitive strategy-specific increases in phosphorylated cAMP response element-binding protein and c-Fos in the hippocampus and dorsal striatum.
TL;DR: The present results indicate that cross maze training causes an initial activation of transcription factors in both the hippocampus and striatum, and formation of memory for a response strategy is related to phosphorylation of CREB in the striatum.
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Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats
TL;DR: Relationships between spatial learning and hippocampal concentrations of calcium-dependent PKC are isoform-specific and age-related spatial memory impairment is associated with altered subcellular concentrations of PKCgamma and may be indicative of deficient signal transduction and neuronal plasticity in the hippocampus.
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Lexical priming deficits as a function of age.
Hasker P. Davis,Alisa Cohen,Michele Gandy,Paul J. Colombo,Gene VanDusseldorp,Neil Simolke,Jane Romano +6 more
TL;DR: The effects of age on implicit memory were assessed in elderly young adults using 2 priming procedures and suggest an age-related decline in both implicit and explicit memory.
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Allocentric spatial and tactile memory impairments in rats with dorsal caudate lesions are affected by preoperative behavioral training.
TL;DR: Results showed that behavioral impairment after damage to the caudate is not restricted to egocentric tasks as previously suggested, but the caUDate seems to be involved in the initial acquisition of information that is invariant over many trials.