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William C. Wetsel
Researcher at Duke University
Publications - 235
Citations - 16954
William C. Wetsel is an academic researcher from Duke University. The author has contributed to research in topics: Protein kinase C & Receptor. The author has an hindex of 63, co-authored 215 publications receiving 15140 citations. Previous affiliations of William C. Wetsel include University of California, San Diego & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.
Raul R. Gainetdinov,William C. Wetsel,Sara R. Jones,Edward D. Levin,Mohamed Jaber,Marc G. Caron +5 more
TL;DR: The parallels between the DAT knockout mice and individuals with ADHD suggest that common mechanisms may underlie some of their behaviors and responses to psychostimulants.
Journal ArticleDOI
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3 -mutant mice
Jeffrey M. Welch,Jing Lu,Ramona M. Rodriguiz,Nicholas C. Trotta,João Peça,Jindong Ding,Catia Feliciano,Meng Chen,J. Paige Adams,Jianhong Luo,Serena M. Dudek,Richard J. Weinberg,Nicole Calakos,William C. Wetsel,Guoping Feng +14 more
TL;DR: It is shown that mice with genetic deletion of Sapap3 exhibit increased anxiety and compulsive grooming behaviour leading to facial hair loss and skin lesions; both behaviours are alleviated by a selective serotonin reuptake inhibitor.
Journal ArticleDOI
Automated design of ligands to polypharmacological profiles
Jérémy Besnard,Gian Filippo Ruda,Vincent Setola,Keren Abecassis,Ramona M. Rodriguiz,Xi Ping Huang,Suzanne Norval,Maria F. Sassano,Antony I. Shin,Lauren A. Webster,Frederick R. C. Simeons,Laste Stojanovski,Annik Prat,Nabil G. Seidah,Daniel B. Constam,G. Richard J. Bickerton,Kevin D. Read,William C. Wetsel,Ian H. Gilbert,Bryan L. Roth,Andrew L. Hopkins +20 more
TL;DR: A new approach for the automated design of ligands against profiles of multiple drug targets, demonstrated by the evolution of an approved acetylcholinesterase inhibitor drug into brain-penetrable ligands with either specific polypharmacology or exquisite selectivity profiles for G-protein-coupled receptors is described.
Journal ArticleDOI
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
Xiaoming Wang,Portia A. McCoy,Ramona M. Rodriguiz,Yanzhen Pan,H. Shawn Je,Adam C. Roberts,Caroline J. Kim,Janet Berrios,Jennifer S. Colvin,Danielle Bousquet-Moore,Isabel Lorenzo,Gang Yi Wu,Richard J. Weinberg,Michael D. Ehlers,Michael D. Ehlers,Benjamin D. Philpot,Arthur L. Beaudet,William C. Wetsel,Yong-hui Jiang +18 more
TL;DR: It is concluded that loss of major Shank3 species produces biochemical, cellular and morphological changes, leading to behavioral abnormalities in mice that bear similarities to human ASD patients with SHANK3 mutations.
Journal ArticleDOI
Mice lacking the norepinephrine transporter are supersensitive to psychostimulants
Fei Xu,Raul R. Gainetdinov,William C. Wetsel,Sara R. Jones,Laura M. Bohn,Gary W. Miller,Gary W. Miller,Yan-Min Wang,Marc G. Caron +8 more
TL;DR: In a classical test for antidepressant drugs, the NET-deficient (NET−/−) animals behaved like antidepressant-treated wild-type mice, and were hyper-responsive to locomotor stimulation by cocaine or amphetamine.