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Paul M. Hassoun
Researcher at Johns Hopkins University
Publications - 308
Citations - 16671
Paul M. Hassoun is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pulmonary hypertension & Medicine. The author has an hindex of 61, co-authored 267 publications receiving 14372 citations. Previous affiliations of Paul M. Hassoun include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Tricuspid annular displacement predicts survival in pulmonary hypertension.
Paul R. Forfia,Micah R. Fisher,Stephen C. Mathai,Traci Housten-Harris,Anna R. Hemnes,Barry A. Borlaug,Elzbieta Chamera,Mary C. Corretti,Hunter C. Champion,Theodore P. Abraham,Reda E. Girgis,Paul M. Hassoun +11 more
TL;DR: TAPSE powerfully reflects RV function and prognosis in PAH and persisted after adjusting for other echocardiographic and hemodynamic variables and baseline treatment status.
Journal ArticleDOI
Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension.
Micah R. Fisher,Paul R. Forfia,Paul R. Forfia,Elzbieta Chamera,Traci Housten-Harris,Hunter C. Champion,Reda E. Girgis,Mary C. Corretti,Paul M. Hassoun +8 more
TL;DR: Doppler echocardiography may frequently be inaccurate in estimating pulmonary artery pressure and cardiac output in patients being evaluated for PH, according to a prospective study on patients with various forms of PH.
Journal ArticleDOI
Endothelial Dysfunction in Pulmonary Hypertension
TL;DR: It is conceivable that the beneficial effects of many of the treatments currently available for PAH result at least in part from restoring the balance between these mediators, such as the use of prostacyclin, NO, and ET antagonists.
Journal ArticleDOI
Inflammation, growth factors, and pulmonary vascular remodeling.
Paul M. Hassoun,Luc Mouthon,Joan Albert Barberà,Saadia Eddahibi,Sonia C. Flores,Friedrich Grimminger,Peter L. Jones,Michael L. Maitland,Evangelos D. Michelakis,Nicholas W. Morrell,John H. Newman,Marlene Rabinovitch,Ralph T. Schermuly,Kurt R. Stenmark,Norbert F. Voelkel,Jason X.-J. Yuan,Marc Humbert +16 more
TL;DR: An overview of specific inflammatory pathways involving cells, chemokines and cytokines, cellular dysfunctions, growth factors, and viral proteins is provided, highlighting their potential role in pulmonary vascular remodeling and the possibility of future targeted therapy.
Journal ArticleDOI
Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury.
Xinqi Peng,Paul M. Hassoun,Saad Sammani,Bryan J. McVerry,Melissa J. Burne,Hamid Rabb,David B. Pearse,Rubin M. Tuder,Joe G.N. Garcia +8 more
TL;DR: It is indicated that S1P significantly decreases pulmonary/renal vascular leakage and inflammation in a murine model of LPS-mediated acute lung injury and may represent a novel therapeutic strategy for vascular barrier dysfunction.