P
Paul Polakis
Researcher at Genentech
Publications - 178
Citations - 17347
Paul Polakis is an academic researcher from Genentech. The author has contributed to research in topics: Wnt signaling pathway & Antibody. The author has an hindex of 51, co-authored 178 publications receiving 16328 citations. Previous affiliations of Paul Polakis include Seattle Genetics & Philips.
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Journal ArticleDOI
Wnt signaling and cancer
TL;DR: In this review, the wnt pathway will be covered from the perspective of cancer, with emphasis placed on molecular defects known to promote neoplastic transformation in humans and in animal models.
Journal ArticleDOI
Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus
Mark Peifer,Paul Polakis +1 more
TL;DR: Two areas of rapid advance are focused on: the machinery that regulates the stability of the key signal transducer, β-catenin, and the effect of Wnt signaling on cellular targets outside the nucleus, the actin and microtubule cytoskeletons.
Journal ArticleDOI
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Jagath Reddy Junutula,Helga Raab,Suzanna Clark,Sunil Bhakta,Douglas D. Leipold,Sylvia Weir,Yvonne Chen,Michelle Simpson,Siao Ping Tsai,Mark S. Dennis,Yanmei Lu,Y Gloria Meng,Carl Ng,Jihong Yang,Chien C Lee,Eileen T. Duenas,Jeffrey Gorrell,Viswanatham Katta,Amy Kim,Kevin McDorman,Kevin McDorman,Kelly Flagella,Rayna Venook,Sarajane Ross,Susan D. Spencer,Wai Lee Wong,Henry B. Lowman,Richard Vandlen,Mark X. Sliwkowski,Richard H. Scheller,Paul Polakis,William Mallet +31 more
TL;DR: The favorable in vivo properties of the near-homogenous composition of this conjugate suggest that the strategy offers a general approach to retaining the antitumor efficacy of antibody-drug conjugates, while minimizing their systemic toxicity.
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Wnt Signaling in Cancer
TL;DR: The evidence supporting a role for Wnt signaling in human cancer is summarized, including a review of the genetic mutations affecting Wnt pathway components, as well as some of epigenetic mechanisms that alter expression of genes relevant to Wnt.
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The many ways of Wnt in cancer.
TL;DR: This review summarizes the reported genetic defects in the Wnt pathway, with an emphasis on their functional contribution to human tumor progression.