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Richard H. Scheller
Researcher at Genentech
Publications - 262
Citations - 43059
Richard H. Scheller is an academic researcher from Genentech. The author has contributed to research in topics: Synaptic vesicle & Syntaxin. The author has an hindex of 109, co-authored 262 publications receiving 41340 citations. Previous affiliations of Richard H. Scheller include Stanford University & Howard Hughes Medical Institute.
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Journal ArticleDOI
SNAREs--engines for membrane fusion.
TL;DR: A fascinating picture of these robust nanomachines is emerging, which seems to be conserved and adaptable for fusion reactions as diverse as those involved in cell growth, membrane repair, cytokinesis and synaptic transmission.
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A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion
TL;DR: It is reported that in the absence of SNAP and NSF, these three SNAREs form a stable complex that can also bind synaptotagmin, suggesting that synapttagmin operates as a "clamp" to prevent fusion from proceeding in the absent of a signal.
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Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal
TL;DR: An antiserum against purified cholinergic synaptic vesicles from Torpedo and expression screening was used to isolate a cDNA clone encoding synuclein, a 143 amino acid neuron-specific protein that is expressed only in nervous system tissue.
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A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis
Maxence V. Nachury,Alexander V. Loktev,Qihong Zhang,Christopher J. Westlake,Johan Peränen,Andreas Merdes,Diane C. Slusarski,Richard H. Scheller,J. Fernando Bazan,Val C. Sheffield,Peter K. Jackson +10 more
TL;DR: The data reveal that BBS may be caused by defects in vesicular transport to the cilium, and a complex composed of seven highly conserved BBS proteins is identified, the BBSome, which localizes to nonmembranous centriolar satellites in the cytoplasm but also to the membrane of the cILium.
Journal ArticleDOI
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Jagath Reddy Junutula,Helga Raab,Suzanna Clark,Sunil Bhakta,Douglas D. Leipold,Sylvia Weir,Yvonne Chen,Michelle Simpson,Siao Ping Tsai,Mark S. Dennis,Yanmei Lu,Y Gloria Meng,Carl Ng,Jihong Yang,Chien C Lee,Eileen T. Duenas,Jeffrey Gorrell,Viswanatham Katta,Amy Kim,Kevin McDorman,Kevin McDorman,Kelly Flagella,Rayna Venook,Sarajane Ross,Susan D. Spencer,Wai Lee Wong,Henry B. Lowman,Richard Vandlen,Mark X. Sliwkowski,Richard H. Scheller,Paul Polakis,William Mallet +31 more
TL;DR: The favorable in vivo properties of the near-homogenous composition of this conjugate suggest that the strategy offers a general approach to retaining the antitumor efficacy of antibody-drug conjugates, while minimizing their systemic toxicity.