Paul Primakoff

TL;DR: The complementary DNA and deduced amino-acid sequences of the mature αand β subunits of PH-30 resemble many viral fusion proteins in both its membrane topology and its predicted binding and fusion functions.

TL;DR: The ADAM gene products with known functions that act in a highly diverse set of biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and the inflammatory response are discussed.

TL;DR: The cloning, sequencing, and characterization of mouse fertilin alpha and beta as well as five additional sequence-similar cDNAs from guinea pig and mouse testis show that the ADAMs are a large, widely expressed, and developmentally regulated family of proteins with multiple potential functions in cell-cell and cell-matrix interactions.

TL;DR: Sperm-egg plasma membrane fusion during fertilization was studied using guinea pig gametes and mAbs to sperm surface antigens and revealed that PH-30 mAb binding was restricted to the sperm posterior head surface and was absent from the equatorial region.

TL;DR: Fertilization is the sum of the cellular mechanisms that pass the genome from one generation to the next and initiate development of a new organism and the gamete molecules and molecular interactions with essential roles in these events are gradually being discovered.