P
Paul R. Shipley
Researcher at University of British Columbia
Publications - 29
Citations - 1012
Paul R. Shipley is an academic researcher from University of British Columbia. The author has contributed to research in topics: Crataegus & Genus. The author has an hindex of 13, co-authored 29 publications receiving 876 citations. Previous affiliations of Paul R. Shipley include University of Washington & Salk Institute for Biological Studies.
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Journal ArticleDOI
A review of the chemistry of the genus Crataegus.
Jennifer E. Edwards,Paula N. Brown,Paula N. Brown,Nadia Talent,Nadia Talent,Timothy A. Dickinson,Timothy A. Dickinson,Paul R. Shipley +7 more
TL;DR: The botany, ethnobotany, and traditional use of hawthorn are reviewed while focusing on the phytochemicals that have been reported in Crataegus species, and the variation in the described chemistry between individual species.
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Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.
Jörn Piel,Christian Hertweck,Paul R. Shipley,Deanna M Hunt,Mark S Newman,Bradley S. Moore,Bradley S. Moore +6 more
TL;DR: The enterocin biosynthesis gene cluster represents the most versatile type II PKS system investigated to date and provides the foundation for engineering hybrid expression sets in the generation of structurally novel compounds for use in drug discovery.
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Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone.
Bradley S. Moore,Christian Hertweck,Jörn Hopke,Miho Izumikawa,John A. Kalaitzis,George Nilsen,Thomas O'Hare,Jörn Piel,Paul R. Shipley,Longkuan Xiang,Michael B. Austin,Joseph P. Noel +11 more
TL;DR: Progress is highlighted on the biochemical and genetic characterization of recently identified streptomycete biosynthetic pathways to benzoic acid and type III polyketide synthase (PKS)-derived products and the discovery that bacteria harbor homodimeric PKSs belonging to the plant CHS superfamily of condensing enzymes.
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Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2)
Miho Izumikawa,Paul R. Shipley,Jörn Hopke,Thomas O'Hare,Longkuan Xiang,Joseph P. Noel,Bradley S. Moore +6 more
TL;DR: Incubation of recombinant THNS with malonyl-CoA showed THN production, as demonstrated by UV and HPLC analyses, and the inactivation, expression, and characterization of the type III PKS homologous SCO1206 gene product as 1,3,6,8-tetrahydroxynaphthalene synthase (THNS) was reported.
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Determination of anthocyanins in cranberry fruit and cranberry fruit products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation.
Paula N. Brown,Paul R. Shipley +1 more
TL;DR: A single-laboratory validation study was conducted on an HPLC method for the detection and quantification of cyanidin-3-O-galactoside (C3Ga, C3Gl, C2Ar, P3 Ga, and P3Ar in cranberry fruit raw material and finished products and results resulted in RSD(r) from 1.77 to 3.31%.