Paul René van Weeren

TL;DR: Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters.

TL;DR: In this article, the authors studied the magnitude and time course of inflammation-induced changes in cartilage tissue turnover as measured in vivo by synovial fluid markers, including inflammatory mediators, matrix metalloproteinase activity and cartilage biomarkers over 1 week in joints with experimentally induced inflammation.

TL;DR: The current challenges to recapitulate the complexity of articulating joints and how biofabrication could overcome them are addressed and the current rapid advances in biofabrics hold significant potential for developing joint‐on‐a‐chip models for personalized medicine and drug testing or even for the creation of implants that may be used to treat larger parts of the articulating joint.

TL;DR: A high performance liquid chromatography-tandem mass spectrometry approach for the simultaneous analysis of multiple eicosanoid lipid mediators in equine synovial fluid is evaluated and its use for investigation of the in vivo effects of non-steroidal anti-inflammatory drug (NSAID) treatment is illustrated.

TL;DR: In this article, the authors characterized the secretion of the potential zonal marker clusterin by zonal articular chondrocytes in osteoarthritic and healthy articular cartilage and in tissue-engineered constructs.