Paul S. Carter

TL;DR: SB-216763 and SB-415286 are novel, potent and selective cell permeable inhibitors of GSK-3 and represent valuable pharmacological tools with which the role of G SKS-3 in cellular signalling can be further elucidated.

TL;DR: Major improvements to the proteolysis targeting chimeras (PROTACs) method are described, a chemical knockdown strategy in which a heterobifunctional molecule recruits a specific protein target to an E3 ubiquitin ligase, resulting in the target's ubiquitination and degradation.

TL;DR: The Axin binding site on GSK-3 presumably overlaps with that for FRATtide; its proximity to the active site explains how Axin may act as a scaffold protein promoting β-catenin phosphorylation.

TL;DR: Crystal structures of this class of potent and specific inhibitors of bacterial tyrosyl‐tRNA synthetases may contribute to the understanding of the catalytic mechanism and provide the structural basis for designing novel antimicrobial agents.

TL;DR: The antimicrobial natural product chuangxinmycin has been found to be a potent and selective inhibitor of bacterial tryptophanyl tRNA synthetase (WRS), and its interaction with WRS appears to be highly constrained, as only sterically smaller analogues afforded significant inhibition.