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Benjamin D. Bax
Researcher at Discovery Institute
Publications - 61
Citations - 4152
Benjamin D. Bax is an academic researcher from Discovery Institute. The author has contributed to research in topics: DNA gyrase & Topoisomerase. The author has an hindex of 29, co-authored 58 publications receiving 3657 citations. Previous affiliations of Benjamin D. Bax include Laboratory of Molecular Biology & GlaxoSmithKline.
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Journal ArticleDOI
Type IIA topoisomerase inhibition by a new class of antibacterial agents.
Benjamin D. Bax,Pan F. Chan,Drake S. Eggleston,Drake S. Eggleston,Andrew P. Fosberry,Daniel R. Gentry,Fabrice Gorrec,Fabrice Gorrec,Ilaria Giordano,Michael M. Hann,Alan Joseph Hennessy,Martin Hibbs,Jianzhong Huang,Emma J. Jones,Jo J. Jones,Kristin K. Brown,Ceri J. Lewis,Earl May,Earl May,Martin R. Saunders,Onkar M. P. Singh,Claus Spitzfaden,Carol Shen,Anthony Shillings,Andrew J. Theobald,Alexandre Wohlkonig,Alexandre Wohlkonig,Neil D. Pearson,Michael N. Gwynn +28 more
TL;DR: This work provides new insights into the mechanism of topoisomerase action and a platform for structure-based drug design of a new class of antibacterial agents against a clinically proven, but conformationally flexible, enzyme class.
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Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation
Huw D. Lewis,John Liddle,Jim E Coote,Stephen John Atkinson,Michael David Barker,Benjamin D. Bax,Kevin L. Bicker,Ryan P. Bingham,Matthew Campbell,Yu Hua Chen,Chun-wa Chung,Peter D. Craggs,Robert P. Davis,Dirk Eberhard,Gerard Joberty,Kenneth E Lind,Kelly Locke,Claire Maller,Kimberly Martinod,Chris Patten,Oxana Polyakova,Cecil E Rise,Martin Rüdiger,Robert J. Sheppard,Daniel J. Slade,Pamela Thomas,Jim Thorpe,Gang Yao,Gerard Drewes,Denisa D. Wagner,Paul R. Thompson,Rab K. Prinjha,David Matthew Wilson +32 more
TL;DR: Novel, selective PAD4 inhibitors binding to a calcium-deficient form of the PAD3 enzyme have been validated, for the first time, in both histone citrullination and neutrophil extracellular trap formation, validating the critical enzymatic role of human and mouse PAD 4.
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The X-ray structure of human serum ceruloplasmin at 3.1.Å: nature of the copper centres
Irina S. Zaitseva,Vjacheslav Zaitsev,Graeme Card,Kirill Moshkov,Benjamin D. Bax,Adam Ralph,P.F. Lindley +6 more
TL;DR: The X-ray structure of human serum ceruloplasmin has been solved at a resolution of 3.1 A as discussed by the authors, which reveals that the molecule is comprised of six plastocyanin-type domains arranged in a triangular array.
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PI 3-kinase: structural and functional analysis of intersubunit interactions.
Ritu Dhand,Hara Kenta,Ian Hiles,Benjamin D. Bax,Ivan Gout,George Panayotou,Michael J. Fry,K. Yonezawa,M. Kasuga,Mike Waterfield +9 more
TL;DR: The predicted structure of p85 suggests a basis for the intersubunit interaction and the relevance of this interaction with respect to the regulation of the PI 3‐kinase complex is discussed.
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Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance
Alexandre Wohlkonig,Pan F. Chan,Andrew P. Fosberry,Paul Homes,Jianzhong Huang,Michael Kranz,Vaughan R. Leydon,Timothy J. Miles,Neil D. Pearson,Rajika L. Perera,Anthony Shillings,Michael N. Gwynn,Benjamin D. Bax +12 more
TL;DR: A crystal structure of moxifloxacin in complex with Acinetobacter baumannii topoisomerase IV now shows the wedge-shaped quinolone stacking between base pairs at the DNA cleavage site and binding conserved residues in theDNA cleavage domain through chelation of a noncatalytic magnesium ion.