P
Paul W. Kopesky
Researcher at Massachusetts Institute of Technology
Publications - 28
Citations - 953
Paul W. Kopesky is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Aggrecan & Cartilage. The author has an hindex of 12, co-authored 27 publications receiving 851 citations.
Papers
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Journal ArticleDOI
Evaluation of adult equine bone marrow- and adipose-derived progenitor cell chondrogenesis in hydrogel cultures.
John D. Kisiday,John D. Kisiday,Paul W. Kopesky,Christopher H. Evans,Alan J. Grodzinsky,C. Wayne McIlwraith,David D. Frisbie +6 more
TL;DR: Both protein and gene expression evidence of superior chondrogenesis of BM‐MSCs relative to ADPCs are shown.
Patent
Methods and apparatus for making particles using spray dryer and in-line jet mill
Donald E. Chickering,Sridhar Narasimhan,David H. Altreuter,Paul W. Kopesky,Mark J. Keegan,Julie A. Straub,Howard Bernstein +6 more
TL;DR: In this article, a single-step spray drying and in-line jet milling process was proposed to deal with the problem of particle deagglomeration and grinding in a single unit operation.
Journal ArticleDOI
Effects of Insulin-like Growth Factor-1 and Dexamethasone on Cytokine-Challenged Cartilage: Relevance to Post Traumatic Osteoarthritis
Yang Li,Yang Wang,S. Chubinskaya,Birgit Schoeberl,Emily Florine,Paul W. Kopesky,Alan J. Grodzinsky +6 more
TL;DR: In this paper, the combined use of insulin-like growth factor-1 (IGF-1) and dexamethasone (Dex) was studied to block the multiple degradative effects of cytokine challenge to articular cartilage.
Journal ArticleDOI
Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells.
TL;DR: It is demonstrated that self-assembling peptide hydrogels enhance chondrogenesis compared with agarose as shown by extracellular matrix production, DNA content, and aggrecan molecular structure.
Journal ArticleDOI
Controlled delivery of transforming growth factor β1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling.
Paul W. Kopesky,Eric J. Vanderploeg,John D. Kisiday,David D. Frisbie,John D. Sandy,Alan J. Grodzinsky +5 more
TL;DR: Robustness of this technology for use in multiple species and ages was demonstrated by effective chondrogenic stimulation of adult equine BMSCs, an important translational model used before the initiation of human clinical studies.