Showing papers in "Journal of Orthopaedic Research in 2008"

TL;DR: Kinematic and kinetic variables at the hip, knee, and ankle joints that change between three clinically distinct levels of knee OA disease severity are identified: asymptomatic, moderate OA, and severe OA.

TL;DR: Your contributions in the area of tendon functional tissue engineering have the potential to create functional load‐bearing repairs that will revolutionize surgical reconstruction after tendon and ligament injury.

TL;DR: In this article, the antimicrobial activity of platelet-leukocyte gel (PLG) against Staphylococcus aureus and the contribution of myeloperoxidase (MPO), present in leukocytes, in this process was investigated.

TL;DR: It is suggested that MSC transplantation may contribute to the maintenance of IVD immune privilege by the differentiation of transplanted MSCs into cells expressing FasL.

TL;DR: The results demonstrate that the forces and motion sustained by the knee are highly activity‐dependent and that the unique loading characteristics for specific activities should be considered for the design of functional and robust total knee replacements, as well as for rehabilitation programs for patients with knee osteoarthritis or following total knee arthroplasty.

TL;DR: Four tests were identified as being sufficient for generating an maximum isometric voluntary contraction (MVIC) in the 12 muscles examined and are recommended as the standard set for normalizing shoulder muscle EMG: abduction 90° with internal rotation (“empty can”), internal rotation in 90° abduction (’internal rotation 90°’), flexion at 125° with scapula resistance (”flexion 125°”, and horizontal adduction at 90° flexion

TL;DR: Both protein and gene expression evidence of superior chondrogenesis of BM‐MSCs relative to ADPCs are shown.

TL;DR: The results of the present study showed that material‐derived osteoinduction significantly enhanced bone healing orthotopically, and that this material property appeared more sensitive for predicting orthotopic performance than physicochemical and structural characteristics.

TL;DR: C cultured chondrocytes undergo dedifferentiation during monolayer culture, although the gene expression level of transcription factors necessary for chondrogenesis remains unchanged, which may prove important for the future development of more specific and efficacious cultivation techniques for human articular chondROcyte‐based therapies.

TL;DR: Results demonstrate that directed cell migration is inducible in human articular chondrocytes and MSC, and PDGF is the most potent factor analyzed, and may be useful to promote tissue integration during cartilage repair or tissue engineering.

TL;DR: Data indicate that circulating osteogenic CTPs are mobilized to fracture site and contribute to osteogenesis in the early stage of fracture healing.

TL;DR: Dynamic knee kinematics were analyzed for normal knees in three activities, including two different types of maximum knee flexion, and no posterior subluxation occurred for either femoral condyle in maximum knee Flexion.

TL;DR: A plane of isotropy for the material properties of meniscal tissue is supported, however, the material behavior is strongly nonlinear because the compressive modulus is several orders of magnitude smaller than previously reported values for tensile modulus.

TL;DR: It is demonstrated that P EMF enhances osteogenic effects of BMP‐2 on MSCs cultured on calcium phosphate substrates, suggesting that PEMF will improve MSC response to B MP‐2 in vivo in a bone environment.

TL;DR: Exclusive comparison of muscle and fasciocutaneous tissue in this novel murine model demonstrates that muscle is superior for the coverage of open tibial fractures for both the rate and quality of fracture healing.

TL;DR: The software appears to be an accurate, consistent, reliable, and reproducible method for analysis of acetabular pathomorphologies and a good‐to‐very good reliability and reproducibility was found for a substantial number of the evaluated radiographicacetabular parameters.

TL;DR: A murine model of implant‐associated OM in which a stainless steel pin is coated with Staphylococcus aureus and implanted transcortically through the tibial metaphysis is developed, demonstrating the first quantitative model of implants that defines the kinetics of microbial growth, osteolysis, and humoral immunity following infection.

TL;DR: The dGEMRIC technique has been used in preliminary clinical studies to understand treatment strategies and to monitor disease, and as such is allowing studies that a decade ago would have been impossible.

TL;DR: It was showed that addition of HA to the medium was able in a dose‐dependent way to reduce the impairment of the mitochondrial membrane potential and to restore mitochondrial ATP production and suppression of inflammatory cytokine activity within the joint.

TL;DR: The results indicate that enhancing vascularization during fracture repair in the elderly may provide unique therapeutic opportunities, and the changes observed are directly correlated with altered expression of biochemical factors that regulate the process of angiogenesis.

TL;DR: Data from the study are the first, to the authors' knowledge, to underscore rhPDGF‐BB efficacy in an injectable beta‐tricalcium phosphate/collagen matrix accelerated fracture repair in a geriatric, osteoporotic rat model.

TL;DR: The hypothesis is that commonly used prolotherapy solutions will induce inflammation (leukocyte and macrophage infiltration) in medial collateral ligaments (MCLs) compared to needlestick, saline injection, and no‐injection controls.

TL;DR: It is suggested that both locking plate systems allow early mobilization of the elbow in patients with osteoporotic bone following fixation of a comminuted distal humerus fracture and improved stability compared with the perpendicular locking system is more indicated.

TL;DR: Large variation in the cartilage stress response between individuals reflects the complex nature of the extensor mechanism and has clinical relevance when considering treatment strategies designed to reduce cartilage stresses by altering femoral internal and external rotation.

TL;DR: Histological analysis of Sprague‐Dawley rats revealed alterations in the rat Achilles tendon that were generally consistent with those described in the literature for diseased human tendon tissues, and likely represent a biological repair/remodeling response resulting from overuse running.

TL;DR: The results showed that the mean COF in the ACL‐deficient knees was significantly greater than that of the no OA (p’< 0.01) and mild OA knees ( p <‬0.001), and lubricin concentrations in the knee groups were significantly lower than that in both of the other groups.

TL;DR: Patellar motion is relatively small with respect to the femur during in vivo weightbearing knee flexion using magnetic resonance imaging and dual orthogonal fluoroscopy, which may provide baseline knowledge for understanding normal patellar tracking.

TL;DR: It is demonstrated that OVX is associated with decrease in BMD (particularly in trabecular bone) and a reduction in the mechanical properties of intact bone and healing fractures and delayed fracture healing.

TL;DR: The results related to meniscal translation and tibio‐menisco‐femoral contact in deep knee flexion, in combination with information about force and pressure in the knee, may lead to a better understanding of the mechanism of meniscal degeneration and osteoarthritis associated with prolonged kneeling and squatting.

TL;DR: The higher muscle cocontraction used by the OAU subjects appears to be an ineffective strategy to stabilize the knee, and should be the focus of future research.