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Paula Desplats
Researcher at University of California, San Diego
Publications - 64
Citations - 7536
Paula Desplats is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Neurodegeneration & Alpha-synuclein. The author has an hindex of 33, co-authored 60 publications receiving 6555 citations. Previous affiliations of Paula Desplats include Scripps Research Institute & University of California, Los Angeles.
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Journal ArticleDOI
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.
Paula Desplats,He Jin Lee,Eun Jin Bae,Christina Patrick,Edward Rockenstein,Leslie Crews,Brian Spencer,Eliezer Masliah,Seung-Jae Lee +8 more
TL;DR: It is shown that α-synuclein is transmitted via endocytosis to neighboring neurons and neuronal precursor cells, forming Lewy-like inclusions, which provide critical insights into the mechanism of pathological progression in PD and other proteinopathies.
Journal ArticleDOI
In vivo demonstration that alpha-synuclein oligomers are toxic.
Beate Winner,Roberto Jappelli,Samir K. Maji,Paula Desplats,Leah Boyer,Stefan Aigner,Claudia Hetzer,Thomas Loher,Marçal Vilar,Silvia Campioni,Christos Tzitzilonis,Alice Soragni,Sebastian Jessberger,Helena Mira,Antonella Consiglio,Emiley Pham,Eliezer Masliah,Fred H. Gage,Roland Riek +18 more
TL;DR: It is shown that α-syn oligomers are toxic in vivo and thatα- syn variants that form oligomers might interact with and potentially disrupt membranes and the toxicity of these mutants by using a rat lentivirus system to investigate loss of dopaminergic neurons in the substantia nigra.
Journal ArticleDOI
Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy
Leslie Crews,Brian Spencer,Paula Desplats,Christina Patrick,Amy Paulino,Edward Rockenstein,Lawrence A. Hansen,Anthony Adame,Douglas Galasko,Eliezer Masliah +9 more
TL;DR: This study supports the notion that defects in the autophagy pathway and more specifically in mTor and Atg7 are associated with neurodegeneration in DLB cases and α-synuclein transgenic models and supports the possibility that modulators of the autophile pathway might have potential therapeutic effects.
Journal ArticleDOI
Antibody-Aided Clearance of Extracellular α-Synuclein Prevents Cell-to-Cell Aggregate Transmission
Eun Jin Bae,He Jin Lee,Edward Rockenstein,Dong Hwan Ho,Eun Bi Park,Na Young Yang,Paula Desplats,Eliezer Masliah,Seung-Jae Lee +8 more
TL;DR: It is shown that antibodies against α- synuclein specifically target and aid in clearance of extracellular α-synuclein proteins by microglia, thereby preventing their actions on neighboring cells.
Journal ArticleDOI
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
Elizabeth A. Thomas,Giovanni Coppola,Paula Desplats,Bin Tang,Elisabetta Soragni,Ryan Burnett,Fuying Gao,Kelsey M. Fitzgerald,Jenna F. Borok,David Herman,Daniel H. Geschwind,Joel M. Gottesfeld +11 more
TL;DR: Chronic oral administration of HDACi 4b, beginning after the onset of motor deficits, significantly improved motor performance, overall appearance, and body weight of symptomatic R6/2300Q transgenic mice, and may offer clinical benefit for HD patients and provide a novel set of potential biomarkers for clinical assessment.