He Jin Lee

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that α-synuclein is transmitted via endocytosis to neighboring neurons and neuronal precursor cells, forming Lewy-like inclusions, which provide critical insights into the mechanism of pathological progression in PD and other proteinopathies.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: It is shown that a small percentage of newly synthesized α-syn is rapidly secreted from cells via unconventional, endoplasmic reticulum/Golgi-independent exocytosis and this finding proves that intravesicular localization and secretion are part of normal life cycle of α- syn and might also contribute to pathological function of this protein.

TL;DR: It is shown that α-synuclein proteins released from neuronal cells are taken up by astrocytes through endocytosis and form inclusion bodies, and this transmission step is thus an important mediator of pathogenic glial responses and could qualify as a new therapeutic target.