P
Paula Leandro
Researcher at University of Lisbon
Publications - 55
Citations - 900
Paula Leandro is an academic researcher from University of Lisbon. The author has contributed to research in topics: Phenylalanine hydroxylase & Cystathionine beta synthase. The author has an hindex of 16, co-authored 49 publications receiving 777 citations.
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Journal ArticleDOI
Protein Misfolding in Conformational Disorders: Rescue of Folding Defects and Chemical Chaperoning
Paula Leandro,Cláudio M. Gomes +1 more
TL;DR: The different types of chemical chaperones are reviewed and discussed and a structural and energetic rationale for their action is provided and reported effects exerted by chemical compounds at different stages of the protein folding process and protein conformational states are discussed.
Journal ArticleDOI
The lytic cassette of mycobacteriophage Ms6 encodes an enzyme with lipolytic activity.
Filipa Gil,Maria João Catalão,José Moniz-Pereira,Paula Leandro,Michael R. McNeil,Madalena Pimentel +5 more
TL;DR: This report describes the activity of a protein encoded by gene lysB from the mycobacteriophage Ms6, believed to be the first description of aprotein with lipolytic activity encoded within a bacteriophages.
Journal ArticleDOI
NO* binds human cystathionine β-synthase quickly and tightly.
João B. Vicente,Henrique G. Colaço,Marisa I. Mendes,Paolo Sarti,Paolo Sarti,Paula Leandro,Alessandro Giuffrè +6 more
TL;DR: For the first time the heme of human CBS is reported to bind NO• quickly and tightly, providing a mechanistic basis for the in vivo regulation of the enzyme by NO•.
Journal ArticleDOI
Glycerol increases the yield and activity of human phenylalanine hydroxylase mutant enzymes produced in a prokaryotic expression system.
TL;DR: It is speculated that correction of protein folding abnormalities by chemical chaperones may be a possible therapeutic approach to correct conformational diseases.
Journal ArticleDOI
Population genetics of hyperphenylalaninaemia resulting from phenylalanine hydroxylase deficiency in Portugal.
TL;DR: The results reported in this study show considerable genetic heterogeneity in the Portuguese PKU population, as has also been described for other southern European populations.