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Paula M. Wagner
Researcher at National University of Cordoba
Publications - 8
Citations - 82
Paula M. Wagner is an academic researcher from National University of Cordoba. The author has contributed to research in topics: Circadian rhythm & CLOCK. The author has an hindex of 3, co-authored 7 publications receiving 38 citations.
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Journal ArticleDOI
Chemotherapeutic Effect of SR9009, a REV-ERB Agonist, on the Human Glioblastoma T98G Cells:
TL;DR: The results suggest that the pharmacological modulation of the tumor-intrinsic clock by REV-ERB agonists severely affects cell metabolism and promotes cytotoxic effects on cancer cells.
Journal ArticleDOI
Proliferative Glioblastoma Cancer Cells Exhibit Persisting Temporal Control of Metabolism and Display Differential Temporal Drug Susceptibility in Chemotherapy
Paula M. Wagner,Lucas Gastón Sosa Alderete,Lucas Gastón Sosa Alderete,Lucas D. Gorné,Lucas D. Gorné,Virginia Lucía Gaveglio,Gabriela Alejandra Salvador,Susana J. Pasquaré,Mario E. Guido +8 more
TL;DR: Investigating whether the human glioblastoma T98G cells maintained quiescent or under proliferation keep a functional clock and whether cells display differential time responses to bortezomib chemotherapy found cross-talk between the transcriptional and the metabolic oscillators.
Journal ArticleDOI
Temporal regulation of tumor growth in nocturnal mammals: In vivo studies and chemotherapeutical potential.
Paula M. Wagner,César G. Prucca,Fabiola N. Velazquez,Lucas G. Sosa Alderete,Beatriz L. Caputto,Mario E. Guido +5 more
TL;DR: In this paper, day/night differences in tumor growth after injection of A530 glioma cells isolated from malignant peripheral nerve sheath tumor (MPNSTs) of NPcis (Trp53+/- ; Nf1+/- ) mice were investigated.
Journal ArticleDOI
Circadian Regulation and Clock-Controlled Mechanisms of Glycerophospholipid Metabolism from Neuronal Cells and Tissues to Fibroblasts.
TL;DR: In this article, the authors examined the control exerted by circadian clocks over GPL metabolism, their synthesizing enzyme expression and activities in normal and tumorous cells of the nervous system and in immortalized fibroblasts.
Posted ContentDOI
Adjusting the Clock: the Importance of Circadian Rhythms in the Development of Glioblastomas and Its Intervention as a Therapeutic Strategy
TL;DR: The present review will discuss state of the art regarding GBM biology, the role of the circadian clock in tumor progression, and new chrono-chemotherapeutic strategies applied for GBM treatment.