Chemotherapeutic Effect of SR9009, a REV-ERB Agonist, on the Human Glioblastoma T98G Cells:
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TLDR
The results suggest that the pharmacological modulation of the tumor-intrinsic clock by REV-ERB agonists severely affects cell metabolism and promotes cytotoxic effects on cancer cells.Abstract:
Glioblastoma multiforme is the most aggressive brain tumor, and human T98G cells constitute a useful glioblastoma multiforme model to evaluate the chemotherapeutic agents. Modern life (shiftwork, j...read more
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Circadian clock genes promote glioma progression by affecting tumour immune infiltration and tumour cell proliferation
Zeyu Wang,Guanhua Su,Ziyu Dai,Ming Meng,Hao Zhang,Fan Fan,Zhengzheng Liu,Longbo Zhang,Longbo Zhang,Nathaniel Weygant,Fengqiong He,Fengqiong He,Ning Fang,Liyang Zhang,Liyang Zhang,Quan Cheng +15 more
TL;DR: Wang et al. as mentioned in this paper explored the relationship between dysregulated circadian clock genes and glioma progression, and a cluster and risk model based on circadian clock gene expression can predict survival outcome.
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Roles of circadian clocks in cancer pathogenesis and treatment.
TL;DR: A review of the role of circadian rhythms in cancer pathogenesis is presented in this article, highlighting the recent advances in chronotherapeutic approaches for improved cancer treatment, and providing mechanistic insights into the therapeutic utility of circadian clocks in cancer treatment.
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Circadian Rhythms, Disease and Chronotherapy:
TL;DR: A review of recent advances in circadian research and the potential for therapeutic applications that take patient circadian rhythms into account in treating disease can be found in this article, where the authors discuss the importance of functional circadian clocks in modulating cellular and organismal responses to physiological cues and pathological insults.
Journal ArticleDOI
Circadian rhythms and cancers: the intrinsic links and therapeutic potentials
TL;DR: In this paper , the authors provide insights into the mechanisms underlying how several types of disruption of the circadian rhythm (including sleep-wake, eating-fasting, and activity-rest) can drive cancer progression, which may expand our understanding of cancer development from the clock perspective.
Journal ArticleDOI
Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling
Zhipeng Su,Zhipeng Su,Shengnan Han,Qiumei Jin,Ningning Zhou,Junwan Lu,Fugen Shangguan,Shiyi Yu,Yongzhang Liu,Lu Wang,Jianglong Lu,Qun Li,Lin Cai,Chengde Wang,Xiaohe Tian,Lingyan Chen,Weiming Zheng,Bin Lu +17 more
TL;DR: In this paper, the effects and underlying molecular mechanisms of Ciclopirox on glioblastoma multiforme (GBM) remain unknown, however, the authors show that CPX displays strong anti-tumorigenic activity on GBM.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Autophagy regulates lipid metabolism
Rajat Singh,Susmita Kaushik,Yongjun Wang,Youqing Xiang,Inna Novak,Masaaki Komatsu,Keiji Tanaka,Ana Maria Cuervo,Mark J. Czaja +8 more
TL;DR: A previously unknown function for autophagy in regulating intracellular lipid stores (macrolipophagy) is identified that could have important implications for human diseases with lipid over-accumulation such as those that comprise the metabolic syndrome.
Journal ArticleDOI
The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator.
Nicolas Preitner,Francesca Damiola,Luis-Lopez-Molina,J. Zakany,Denis Duboule,Urs Albrecht,Ueli Schibler +6 more
TL;DR: The orphan nuclear receptor REV-ERBalpha is identified as the major regulator of cyclic Bmal1 transcription, and constitutes a molecular link through which components of the negative limb drive antiphasic expression of component of the positive limb.
Journal ArticleDOI
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Nicholas Gekakis,David Staknis,David Staknis,David Staknis,Hubert B. Nguyen,Hubert B. Nguyen,Hubert B. Nguyen,Fred C. Davis,Fred C. Davis,Fred C. Davis,Lisa D. Wilsbacher,Lisa D. Wilsbacher,Lisa D. Wilsbacher,David P. King,David P. King,David P. King,Joseph S. Takahashi,Joseph S. Takahashi,Joseph S. Takahashi,Charles J. Weitz,Charles J. Weitz,Charles J. Weitz +21 more
TL;DR: CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity.
Journal ArticleDOI
Circadian Integration of Metabolism and Energetics
Joseph Bass,Joseph S. Takahashi +1 more
TL;DR: Advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes are reviewed and implications for rational therapeutics for these conditions are reviewed.