P
Paule Opolon
Researcher at Institut Gustave Roussy
Publications - 171
Citations - 18425
Paule Opolon is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 54, co-authored 168 publications receiving 15233 citations. Previous affiliations of Paule Opolon include Université Paris-Saclay & French Institute of Health and Medical Research.
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Journal ArticleDOI
Regorafenib: Antitumor Activity upon Mono and Combination Therapy in Preclinical Pediatric Malignancy Models.
Estelle Daudigeos-Dubus,Estelle Daudigeos-Dubus,Estelle Daudigeos-Dubus,Ludivine Le Dret,Ludivine Le Dret,Ludivine Le Dret,Claudia Lanvers-Kaminsky,Olivia Bawa,Paule Opolon,Albane Vievard,Irène Villa,Mélanie Pagès,Jacques Bosq,Gilles Vassal,Gilles Vassal,Gilles Vassal,Dieter Zopf,B. Geoerger,B. Geoerger,B. Geoerger +19 more
TL;DR: It is demonstrated that regorafenib exhibits significant antitumor activity in a wide spectrum of preclinical pediatric models through inhibition of angiogenesis and induction of apoptosis and radio- and chemosensitizing effects were observed with DNA damaging agents in PDGFR amplified tumors.
Journal ArticleDOI
The role of IL-6 in the inflammatory and humoral response to adenoviral vectors.
Karim Benihoud,Barbara Salone,Stéphanie Esselin,Paule Opolon,Valeria Poli,Monica Di Giovine,Michel Perricaudet,Isabella Saggio +7 more
TL;DR: In vivo studies and clinical trials with recombinant adenovirus have suggested a role for interleukin 6 (IL‐6) in the inflammatory reaction that follows Ad‐infection.
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The IGR-CaP1 xenograft model recapitulates mixed osteolytic/blastic bone lesions observed in metastatic prostate cancer.
Nader Al Nakouzi,Olivia Bawa,Alain Le Pape,Alain Le Pape,Stéphanie Lerondel,Catherine Gaudin,Paule Opolon,Patrick Gonin,Karim Fizazi,Anne Chauchereau +9 more
TL;DR: The IGR-CaP1 cell line is a unique model derived from a primary tumor, which can reconstitute human prostate adenocarcinoma in animals and generate experimental bone metastases, providing a novel means for understanding the mechanisms of bone metastasis progression and allowing preclinical testing of new therapies.
Journal Article
Combined Radiation Sensitizing and Anti-angiogenic Effects of Ionizing Radiation and the Protease Inhibitor Ritonavir in a Head and Neck Carcinoma Model
TL;DR: The antitumor effect of the latter combination is associated with the enhancement of radiation-induced apoptosis and inhibition of angiogenesis, suggesting that Ritonavir could clinically improve the tumor response to radiation therapy, especially in head and neck carcinoma.
Journal ArticleDOI
Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients.
Joseph Saliba,Joseph Saliba,Sofiane Hamidi,Sofiane Hamidi,Gaëlle Lenglet,Gaëlle Lenglet,Thierry Langlois,Thierry Langlois,Jingkui Yin,Xénia Cabagnols,Xénia Cabagnols,Lise Secardin,Lise Secardin,Céline Legrand,Céline Legrand,Anne Galy,Paule Opolon,Baya Benyahia,Eric Solary,Eric Solary,Olivier Bernard,Olivier Bernard,Longyun Chen,Najet Debili,Najet Debili,Hana Raslova,Hana Raslova,Françoise Norol,Françoise Norol,William Vainchenker,William Vainchenker,Isabelle Plo,Isabelle Plo,Antonio Di Stefano,Antonio Di Stefano +34 more
TL;DR: The derivation of induced pluripotent stem (iPS) cell lines from 2 polycythemia vera patients carrying a heterozygous and a homozygous mutated JAK2V617F brings the proof of concept that iPS can be used for studying MPN pathogenesis, clonal architecture, and drug efficacy.