V
Valeria Poli
Researcher at University of Turin
Publications - 177
Citations - 20548
Valeria Poli is an academic researcher from University of Turin. The author has contributed to research in topics: STAT3 & STAT protein. The author has an hindex of 70, co-authored 169 publications receiving 18977 citations. Previous affiliations of Valeria Poli include Brigham and Women's Hospital & University of Perugia.
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Journal ArticleDOI
Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
Drew E. Cressman,Linda E. Greenbaum,Robert A. DeAngelis,Gennaro Ciliberto,Emma E. Furth,Valeria Poli,Rebecca Taub +6 more
TL;DR: Treatment ofIL-6-deficient mice with a single preoperative dose of IL-6 returned STAT3 binding, gene expression, and hepatocyte proliferation to near normal and prevented liver damage, establishing that IL- 6 is a critical component of the regenerative response.
Journal ArticleDOI
Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment
Maria Romano,Marina Sironi,Carlo Toniatti,Nadia Polentarutti,Paolo Fruscella,Pietro Ghezzi,Raffaella Faggioni,Walter Luini,Victor W.M. van Hinsbergh,Silvano Sozzani,Federico Bussolino,Valeria Poli,Gennaro Ciliberto,Alberto Mantovani,Alberto Mantovani +14 more
TL;DR: In vivo and in vitro evidence supports the concept that the IL-6 system plays an unexpected positive role in local inflammatory reactions by amplifying leukocyte recruitment.
Journal ArticleDOI
Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion.
Valeria Poli,R. Balena,Elena Fattori,Angelo Markatos,M. Yamamoto,Hirofumi Tanaka,Gennaro Ciliberto,Gideon A. Rodan,Frank Costantini +8 more
TL;DR: It is reported that IL‐6 deficient mice generated by gene targeting are viable and do not present any evident phenotypic abnormality, and analysis of bone metabolism revealed a specific bone phenotype, indicating that IL-6 plays an important role in the local regulation of bone turnover.
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A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy
Denise Hilfiker-Kleiner,Karol Kamiński,Edith Podewski,Tomasz A. Bonda,Arnd Schaefer,Karen Sliwa,Olaf Forster,Anja Quint,Ulf Landmesser,Carola Doerries,Maren Luchtefeld,Valeria Poli,Michael D. Schneider,Jean-Luc Balligand,Fanny Desjardins,Aftab A. Ansari,Ingrid Struman,Ngoc Quynh Nhu Nguyen,Nils H. Zschemisch,Gunnar Klein,Gerd Heusch,Rainer Schulz,Andres Hilfiker,Helmut Drexler +23 more
TL;DR: It is shown that female mice with a cardiomyocyte-specific deletion of stat3 develop PPCM, implying that inhibition of prolactin release may represent a novel therapeutic strategy for P PCM.
Journal ArticleDOI
The Role of C/EBP Isoforms in the Control of Inflammatory and Native Immunity Functions
TL;DR: The CAAT/enhancer-binding proteins (C/EBPs) are a family of leucine zipper transcription factors involved in the regulation of various aspects of cellular differentiation and function in multiple tissues as discussed by the authors.