Pauline Maffre

TL;DR: Even though the P EG coatings did not completely prevent protein adsorption, the PEGylated NPs still displayed a pronounced reduction of cellular uptake with respect to bare NPs, which is to be expected if the adsorbed proteins are not exposed on the NP surface.

TL;DR: In this review an analysis of existing experimental data about the protein corona, and an outline for required future work will be given, how existing simple analytical models such as the adopted Hill model may help to extract quantitative data from such experiments such as equilibrium dissociation and kinetic coefficients are reviewed.

TL;DR: In this article, a human serum albumin (HSA) was modified by succinic anhydride (HSAsuc) to generate additional carboxyl groups on the protein surface, which showed a 3-fold decreased binding affinity toward the nanoparticles.

TL;DR: The results indicate that the degree of protein coverage and the composition of the adsorbed proteins on the NPs' surface depend on the temperature at which the protein corona is formed, and the uptake of NPs is affected by the temperature.

TL;DR: Using dual-focus fluorescence correlation spectroscopy, the adsorption of three human blood serum proteins onto polymer-coated, fluorescently labeled FePt nanoparticles carrying negatively charged carboxyl groups on their surface is analyzed, suggesting the formation of protein monolayers that enclose the nanoparticles.