P
Pilar Ruiz-Lozano
Researcher at Stanford University
Publications - 78
Citations - 11132
Pilar Ruiz-Lozano is an academic researcher from Stanford University. The author has contributed to research in topics: Mutant & Cellular differentiation. The author has an hindex of 40, co-authored 77 publications receiving 10304 citations. Previous affiliations of Pilar Ruiz-Lozano include The Texas Heart Institute & Discovery Institute.
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Journal ArticleDOI
PPAR gamma is required for placental, cardiac, and adipose tissue development.
Yaacov Barak,Michael C. Nelson,Michael C. Nelson,Estelita S. Ong,Estelita S. Ong,Ying Jones,Pilar Ruiz-Lozano,Kenneth R. Chien,Alan Koder,Ronald M. Evans,Ronald M. Evans +10 more
TL;DR: Findings both confirm and expand the current known spectrum of physiological functions regulated by PPAR gamma, implicating a previously unrecognized dependence of the developing heart on a functional placenta.
Journal ArticleDOI
MicroRNA-133 controls cardiac hypertrophy
Alessandra Carè,Daniele Catalucci,Federica Felicetti,Désirée Bonci,Antonio Addario,Paolo Gallo,Marie Louise Bang,Patrizia Segnalini,Yusu Gu,Nancy D. Dalton,Leonardo Elia,Michael V.G. Latronico,Morten A. Høydal,Camillo Autore,Matteo Antonio Russo,Gerald W. Dorn,Øyvind Ellingsen,Pilar Ruiz-Lozano,Kirk L. Peterson,Carlo M. Croce,Cesare Peschle,Gianluigi Condorelli +21 more
TL;DR: The data show thatmiR-133, and possibly miR-1, are key regulators of cardiac hypertrophy, suggesting their therapeutic application in heart disease.
Journal ArticleDOI
Identification of a Wnt/Dvl/β-Catenin → Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development
Chrissa Kioussi,Paola Briata,Sung Hee Baek,David W. Rose,Natasha S. Hamblet,Thomas Herman,Kenneth A. Ohgi,Chijen Lin,Anatoli S. Gleiberman,Jianbo Wang,Véronique Brault,Pilar Ruiz-Lozano,Hoang Duy Nguyen,Rolf Kemler,Christopher K. Glass,Anthony Wynshaw-Boris,Michael G. Rosenfeld +16 more
TL;DR: The bicoid-related transcription factor Pitx2 is rapidly induced by the Wnt/Dvl/beta-catenin pathway and is required for effective cell-type-specific proliferation by directly activating specific growth-regulating genes.
Journal ArticleDOI
Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II
Joseph R. Marszalek,Pilar Ruiz-Lozano,Elizabeth A. Roberts,Kenneth R. Chien,Lawrence S.B. Goldstein +4 more
TL;DR: It is demonstrated that the kinesin-based transport pathway needed for flagellar and ciliary morphogenesis is conserved from Chlamydomonas to mammals and support the view that embryonic cilia play a role in the earliest cellular determinative events establishing L-R asymmetry.
Journal ArticleDOI
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure
Natasha S. Hamblet,Nardos Lijam,Pilar Ruiz-Lozano,Jianbo Wang,Yasheng Yang,Zhenge Luo,Lin Mei,Kenneth R. Chien,Daniel J. Sussman,Anthony Wynshaw-Boris,Anthony Wynshaw-Boris +10 more
TL;DR: Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure, and there is functional redundancy between Dvl1 and Dvl2 in some phenotypes.