P
Pauline T. Lukey
Researcher at GlaxoSmithKline
Publications - 71
Citations - 4974
Pauline T. Lukey is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Idiopathic pulmonary fibrosis & Mycobacterium tuberculosis. The author has an hindex of 32, co-authored 71 publications receiving 4434 citations. Previous affiliations of Pauline T. Lukey include University of Pretoria.
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Journal ArticleDOI
Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling.
TL;DR: A model in which M. tuberculosis arrests growth, decreases its respiration rate and is resistant to isoniazid, rifampicin and metronidazole is established, which is generated a model with which to search for agents active against persistent M.culosis.
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Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study
R. Gisli Jenkins,Juliet Kay Simpson,Gauri Saini,Jane H Bentley,Anne-Marie Russell,Rebecca Braybrooke,Philip L. Molyneaux,Tricia M. McKeever,Athol U. Wells,Aiden A. Flynn,Richard Hubbard,Diana Julie Leeming,Richard P. Marshall,Morten A. Karsdal,Pauline T. Lukey,Toby M. Maher,Toby M. Maher +16 more
TL;DR: Whether dynamic change in markers of extracellular matrix (ECM) turnover predicts progression of idiopathic pulmonary fibrosis as determined by change in forced vital capacity and death is investigated.
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Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response.
Jacqueline M. Cliff,Ji-Sook Lee,Nicholas Constantinou,Jang-Eun Cho,Taane G. Clark,Katharina Ronacher,Elizabeth C. King,Pauline T. Lukey,Ken Duncan,Paul D. van Helden,Gerhard Walzl,Hazel M. Dockrell +11 more
TL;DR: Measurement of biosignatures during clinical trials of new drugs could be useful predictors of rapid bactericidal or sterilizing drug activity, and would expedite the licensing of new treatment regimens.
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In Situ Detection of Mycobacterium tuberculosis Transcripts in Human Lung Granulomas Reveals Differential Gene Expression in Necrotic Lesions
Gael Fenhalls,Liesel Stevens,Lorraine Moses,Juanita Bezuidenhout,Joanna Betts,Paul D. van Helden,Pauline T. Lukey,Ken Duncan +7 more
TL;DR: The differential expression of genes within granulomas demonstrates that M. tuberculosis exists in a variety of metabolic states and may be indicative of the response to different microenvironments and confirm that genes identified in models of persistence or in response to drug treatment in vitro are expressed in the human host.
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An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study.
Toby M. Maher,Eunice Oballa,Juliet Kay Simpson,Joanne Porte,Joanne Porte,Anthony Habgood,William A. Fahy,Aiden A. Flynn,Philip L. Molyneaux,Rebecca Braybrooke,Rebecca Braybrooke,Hrushikesh Divyateja,Helen Parfrey,Doris M Rassl,Anne-Marie Russell,Gauri Saini,Gauri Saini,Elisabetta A. Renzoni,Anne-Marie Duggan,Richard Hubbard,Richard Hubbard,Athol U. Wells,Pauline T. Lukey,Richard P. Marshall,R. Gisli Jenkins,R. Gisli Jenkins +25 more
TL;DR: This study has identified serum proteins secreted from metaplastic epithelium that can be used to predict disease progression and death in IPF.