H
Helen Parfrey
Researcher at Papworth Hospital
Publications - 24
Citations - 1089
Helen Parfrey is an academic researcher from Papworth Hospital. The author has contributed to research in topics: Idiopathic pulmonary fibrosis & Interstitial lung disease. The author has an hindex of 9, co-authored 23 publications receiving 553 citations. Previous affiliations of Helen Parfrey include British Thoracic Society & Cambridge University Hospitals NHS Foundation Trust.
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Journal ArticleDOI
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study
Richard J. Allen,Joanne Porte,Rebecca Braybrooke,Carlos Flores,Tasha E. Fingerlin,Justin M. Oldham,Beatriz Guillen-Guio,Shwu-Fan Ma,Tsukasa Okamoto,Alison E. John,Ma'en Obeidat,Ivana V. Yang,Amanda P. Henry,Richard Hubbard,Vidya Navaratnam,Gauri Saini,Norma Thompson,Helen Booth,Simon P. Hart,Michael Hill,Nik Hirani,Toby M. Maher,Robin J. McAnulty,Ann B. Millar,Philip L. Molyneaux,Helen Parfrey,Doris M Rassl,Moira K. B. Whyte,William A. Fahy,Richard P. Marshall,Eunice Oballa,Yohan Bossé,David C. Nickle,Don D. Sin,Wim Timens,Nick Shrine,Ian Sayers,Ian P. Hall,Imre Noth,David A. Schwartz,Martin D. Tobin,Louise V. Wain,Louise V. Wain,R. Gisli Jenkins +43 more
TL;DR: The identification of AKAP13 as a susceptibility gene for IPF increases the prospect of successfully targeting RhoA pathway inhibitors in patients with IPF.
Journal ArticleDOI
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.
Richard J. Allen,Beatriz Guillen-Guio,Justin M. Oldham,Shwu-Fan Ma,Amy Dressen,Megan L. Paynton,Luke M. Kraven,Ma'en Obeidat,Xuan Li,Michael Ng,Rebecca Braybrooke,Maria Molina-Molina,Maria Molina-Molina,Brian D. Hobbs,Rachel K. Putman,Phuwanat Sakornsakolpat,Helen Booth,William A. Fahy,Simon P. Hart,Michael Hill,Nik Hirani,Richard Hubbard,Robin J. McAnulty,Ann B. Millar,Vidyia Navaratnam,Eunice Oballa,Helen Parfrey,Gauri Saini,Moira K. B. Whyte,Yingze Zhang,Naftali Kaminski,Ayodeji Adegunsoye,Mary E. Strek,Margaret Neighbors,Xuting R. Sheng,Gunnar Gudmundsson,Vilmundur Gudnason,Hiroto Hatabu,David J. Lederer,Ani Manichaikul,John D. Newell,John D. Newell,George T. O'Connor,George T. O'Connor,Victor E. Ortega,Hanfei Xu,Tasha E. Fingerlin,Yohan Bossé,Ke Hao,Philippe Joubert,David C. Nickle,Don D. Sin,Wim Timens,Wim Timens,Dominic Furniss,Andrew P. Morris,Andrew P. Morris,Krina T. Zondervan,Ian P. Hall,Ian P. Hall,Ian Sayers,Ian Sayers,Martin D. Tobin,Martin D. Tobin,Toby M. Maher,Toby M. Maher,Michael H. Cho,Gary M. Hunninghake,David A. Schwartz,Brian L. Yaspan,Philip L. Molyneaux,Philip L. Molyneaux,Carlos Flores,Imre Noth,R. Gisli Jenkins,R. Gisli Jenkins,Louise V. Wain,Louise V. Wain +77 more
TL;DR: The observation that decreased DEPTOR expression associates with increased susceptibility to IPF supports recent studies demonstrating the importance of mTOR signaling in lung fibrosis, and new signals of association implicating KIF15 and MAD1L1 suggest a possible role of mitotic spindle-assembly genes in IPF susceptibility.
Journal ArticleDOI
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study
Thomas M Drake,Annemarie B Docherty,Ewen M Harrison,Jennifer K Quint,Huzaifa Adamali,Huzaifa Adamali,Sarah Agnew,Suresh Babu,Chris Barber,Shaney L Barratt,Shaney L Barratt,Elisabeth Bendstrup,Stephen Bianchi,Diego Castillo Villegas,Nazia Chaudhuri,Felix Chua,R K Coker,William Chang,Anjali Crawshaw,Louise E. Crowley,Davinder Dosanjh,Christine A Fiddler,Ian Forrest,Peter M. George,Michael A Gibbons,Katherine Groom,Sarah Haney,Simon P. Hart,Emily Heiden,Michael Henry,Ling-Pei Ho,Rachel K. Hoyles,John M. Hutchinson,Killian Hurley,Killian Hurley,Mark Jones,S Jones,Maria Kokosi,Michael Kreuter,Laura Mackay,Siva Mahendran,George Margaritopoulos,Maria Molina-Molina,Philip L. Molyneaux,Aidan O'Brien,Katherine M.A. O'Reilly,Alice Packham,Helen Parfrey,Venerino Poletti,Joanna C. Porter,Elisabetta A. Renzoni,Pilar Rivera-Ortega,Anne-Marie Russell,Anne-Marie Russell,Gauri Saini,Lisa G. Spencer,Giulia M. Stella,Helen Stone,Sharon Sturney,David R Thickett,David R Thickett,Muhunthan Thillai,Tim Jm Wallis,Katie Ward,Athol U. Wells,Alex West,Melissa Wickremasinghe,Felix Woodhead,Glenn Hearson,Lucy Howard,J Kenneth Baillie,Peter J. M. Openshaw,Malcolm G Semple,Malcolm G Semple,Iain A. Stewart,R. Gisli Jenkins,R. Gisli Jenkins,Isaric C Investigators +77 more
TL;DR: Patients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity, and Stringent precautions should be taken to avoid CO VID-19 in patients with I LD.
Journal ArticleDOI
An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study.
Toby M. Maher,Eunice Oballa,Juliet Kay Simpson,Joanne Porte,Joanne Porte,Anthony Habgood,William A. Fahy,Aiden A. Flynn,Philip L. Molyneaux,Rebecca Braybrooke,Rebecca Braybrooke,Hrushikesh Divyateja,Helen Parfrey,Doris M Rassl,Anne-Marie Russell,Gauri Saini,Gauri Saini,Elisabetta A. Renzoni,Anne-Marie Duggan,Richard Hubbard,Richard Hubbard,Athol U. Wells,Pauline T. Lukey,Richard P. Marshall,R. Gisli Jenkins,R. Gisli Jenkins +25 more
TL;DR: This study has identified serum proteins secreted from metaplastic epithelium that can be used to predict disease progression and death in IPF.
Journal ArticleDOI
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study
Tracy Hussell,Ramsey Sabit,Rachel Upthegrove,Daniel M. Forton,T Soulsby,Pádraig T. Kitterick,H. Lamlum,Prathiba Kurupati,Dinesh Saralaya,Sylviane Defres,Elizabeth M. Tunnicliffe,V. Turner,Ruvini Dharmagunawardena,Laurene M. Ratcliffe,Sven Plein,Ross Stimpson,Elizabeth M. Bright,Stephen P. McAdoo,Rob Baggott,Peter Jezzard,D. Sowter,Todd R. Hazelton,Hector Chinoy,Charles F. Lynch,Davies Adeloye,Grant Landers,Richard Morriss,L Gilmour,Charlotte L. Edwardson,Scott M. Palmer,Colin Overton,Chris Carr,Linda Allan,Hans Fisher,H. Newell,Shamyla Siddique,G. Webster Ross,C. P. Singh,Claudia E. Vickers,Laurie J. Morrison,David J. Burn,V.Ann Lewis,Shivani Misra,Cassandra Brookes,David C. Johnston,Sandra Edwards,Serena Coetzee,Paul J. Novotny,D. C. Griffin,T. Gorsuch,Layne T. Watson,Sophie Jose,B. D. Cooper,E Clare Harris,Bakthisaran Raman,Gail Carson,Ssc Kon,Lorcan McGarvey,Patrick McArdle,Simon Heller,C. Barr Taylor,Edward L. Robinson,Ludger Wilhelm Poll,Lucy C. Garner,Shaun Kerr,V. R. Brown,Liam O'Brien,Hilary Tedd,Daniel J. Cuthbertson,Elizabeth Sapey,Robin J. Evans,Holly Foot,Vanessa Shaw,Ed Major,Georgios Kaltsakas,Pedro Almeida,Stephen R. Stockdale,T. Newman,T Hiwot,Teresa R. Wallis,David C. Wraith,Helen McShane,Leah Burden,L. Austin,Gill Arbane,Ray Butcher,B Hargadon,Philip C. Calder,B. Vinson,Luke Daines,S. Betts,Terrence Nicholson,E McIvor,S.A. Payne,Gillian Coakley,Huzaifa Adamali,Umakanta Nanda,S. Walsh,Louise Stadon,T. McNally,P Atkin,E. Davies,Helena G. Ramos,Helena G. Ramos,E. Richardson,C. M. Brown,D Redwood,David A. Lomas,P. W. Carter,S.J. Holden,Helen Parfrey,C McGee,T. Rees,L N Holdsworth,L. Stephenson,L. Finnigan,Chris Laing,B Bang,R. Samuel,B Al-Sheklly,Lydia Warburton,Roche L,Sam Haq,Lisa Zeidan,Claire Kurasz,Tina Burdett,Eva Beranova,Edmund Pacpaco,Susannah Thackray-Nocera,Enya Daynes,Brigid Hairsine,Toby Hillman,Elena Lukaschuk,Emma Baldry,Vicky Kamwa,Inez Wynter,Hannah Bayes,Paul Fraser Harrison,Shannon Amoils,Leanne Osborne,T. 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TL;DR: The Post-hospitalisation COVID-19 study (PHOSP-COVID) as mentioned in this paper is a prospective, longitudinal cohort study recruiting adults (aged ≥18 years) discharged from hospital with COVID19 across the UK.