P
Paulo Loureiro de Sousa
Researcher at University of Strasbourg
Publications - 68
Citations - 3534
Paulo Loureiro de Sousa is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Dementia with Lewy bodies & Thought disorder. The author has an hindex of 22, co-authored 62 publications receiving 2518 citations. Previous affiliations of Paulo Loureiro de Sousa include University of Liverpool & Centre national de la recherche scientifique.
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Journal ArticleDOI
Non-invasive assessment of skeletal muscle fibrosis in mice using nuclear magnetic resonance imaging and ultrasound shear wave elastography.
A.B. Martins-Bach,Damien Bachasson,Ericky C. A. Araujo,Lucas Soustelle,Paulo Loureiro de Sousa,Yves Fromes,Pierre G. Carlier +6 more
TL;DR: In this paper, a mouse model with variable levels of induced skeletal muscle fibrosis displaying minimal inflammation and no fat infiltration was described, and how fibrosis affects non-invasive metrics derived from nuclear magnetic resonance (NMR) and ultrasound shear-wave elastography (SWE) associated with a passive biomechanical assay.
Posted ContentDOI
Multi-influential interactions alters behaviour and cognition through six main biological cascades in Down syndrome mouse models
Yann Herault,Arnaud Duchon,Maria del Mar Muniz Moreno,Sandra Martin Lorenzo,Marcia Priscilla Silva de Souza,Claire Chevalier,Valérie Nalesso,Hamid Meziane,Paulo Loureiro de Sousa,Vincent Noblet,Jean-Paul Armspach,Véronique Brault +11 more
TL;DR: Taking advantage of DS mouse models, behavior and cognition, brain morphology and hippocampal gene expression are investigated in a controlled environment and it is unraveled how multiple genetic interactions between different regions of the chromosome 21 contribute in altering the outcome of the behavioural, morphological and molecular/pathways phenotypes.
Journal ArticleDOI
MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies
Anna Inguanzo,Konstantinos Dipl Che Poulakis,Rosaleena Mohanty,Christopher G. Schwarz,Scott A. Przybelski,Patricia Diaz-Galvan,A. J. Lowe,Bradley F. Boeve,Afina W. Lemstra,M. van de Beek,Wiesje M. van der Flier,Frederik Barkhof,F. Blanco,Paulo Loureiro de Sousa,Nathalie Philippi,Benjamin Cretin,Catherine Demuynck,Zuzana Nedelska,Jakub Hort,Bàrbara Segura,Carme Junqué,Ketil Oppedal,Dag Aarsland,Eric Westman,Kejal Kantarci,Daniel Ferreira +25 more
TL;DR: In this article , the authors used data-driven analysis of magnetic resonance imaging (MRI) data to investigate DLB subtypes, and identified three subtypes: an older subtype with reduced cortical GM volumes, worse cognition, and faster cognitive decline.
Journal ArticleDOI
Multi-parametric quantitative MRI reveals three different white matter subtypes.
Jack R. Foucher,Olivier Mainberger,Julien Lamy,Mathieu Santin,Alexandre Vignaud,Mathilde M Roser,Paulo Loureiro de Sousa +6 more
TL;DR: In this paper, the authors used quantitative multi-parametric MRI to evaluate in what respect these inhomogeneities could correspond to brain white matter subtypes with specific characteristics and spatial distribution.
neuromuscular diseases useful for studying physiopathological mechanisms and testing therapies
P.C.M. Martins,D. Ayub-Guerrieri,A.B. Martins-Bach,P.C.G. Onofre-Oliveira,Jackeline Moraes Malheiros,Alberto Tannus,Paulo Loureiro de Sousa,Pierre G. Carlier,Mariz Vainzof +8 more
TL;DR: The new Dmdmdx/Largemyd mouse model is viable and shows a severe phenotype that is associated with the lack of dystrophin in muscle, and has proven to be very useful for the study of several other therapies, because injected cells can be screened both through DNA and protein analysis.