Iron Catalysis in Organic Synthesis

The coupling of aryl or vinyl halides with terminal acetylenes catalysed by palladium and other transition metals, commonly termed as Sonogashira cross-coupling reaction, is one of the most important and widely used sp2–sp carbon–carbon bond formation reactions in organic synthesis, frequently employed in the synthesis of natural products, biologically active molecules, heterocycles, molecular electronics, dendrimers and conjugated polymers or nanostructures. This critical review focuses on developments in the Sonogashira reaction achieved in recent years concerning catalysts, reaction conditions and substrates (352 references).

Recent advances in Sonogashira reactions

https://eprints.ncl.ac.uk/file_store/production/162122/B5324BA5-F503-4BE9-947E-6F7ED01AAD04.pdf

Synthesis of cyclic carbonates from epoxides and CO2

Late transition metal-catalyzed hydroamination and hydroamidation.

Palladium-catalyzed carbonylative coupling reactions of aromatic halides and related compounds have undergone a rapid development during recent years. Nowadays, a plethora of palladium catalysts are available for the synthesis of ketones, alkynones, chalcones, etc., which are important intermediates in the manufacture of dyes, pharmaceuticals, agrochemicals, and other industrial products. In this critical review, we summarize the development of these carbonylative transformations with carbon nucleophiles (136 references).

Palladium-catalyzed carbonylative coupling reactions between Ar–X and carbon nucleophiles

Pd/C: An Efficient, Heterogeneous and Reusable Catalyst for Phosphane‐Free Carbonylative Suzuki Coupling Reactions of Aryl and Heteroaryl Iodides

Synthesis of quinazoline-2,4(1H,3H)-diones from carbon dioxide and 2-aminobenzonitriles using [Bmim]OH as a homogeneous recyclable catalyst

Pd/C : an efficient, heterogeneous and reusable catalyst for carbon monoxide-free aminocarbonylation of aryl iodides

A novel method for cyanation of aryl halides using formamide as a non-toxic cyanide source is reported. It is a single-step, solvent-free method wherein formamide itself acts as solvent as well as source of cyanide in the presence of phosphorus oxychloride and palladium acetate/xantphos catalyst. Aryl iodides as well as aryl bromides provided moderate to excellent yields of up to 93%.

Cyanides-Free Cyanation of Aryl Halides using Formamide

An efficient protocol for the synthesis of quinazoline-2,4(1H,3H)-diones derivatives from 2-aminobenzonitriles with carbon dioxide using catalytic amount of cesium carbonate has been developed. 6,7-Dimethoxyquinazoline-2,4(1H,3H)-dione, which is one of the key intermediate for the synthesis of several drugs (Prazosin, Bunazosin and Doxazosin) was synthesized. The effect of different reaction parameters like influences of bases, solvent, temperature, CO2 pressure and reaction time were investigated for the title reaction.

Pawan J. Tambade

Papers

Pd/C: An Efficient, Heterogeneous and Reusable Catalyst for Phosphane‐Free Carbonylative Suzuki Coupling Reactions of Aryl and Heteroaryl Iodides

Synthesis of quinazoline-2,4(1H,3H)-diones from carbon dioxide and 2-aminobenzonitriles using [Bmim]OH as a homogeneous recyclable catalyst

Pd/C : an efficient, heterogeneous and reusable catalyst for carbon monoxide-free aminocarbonylation of aryl iodides

Cyanides-Free Cyanation of Aryl Halides using Formamide

Cesium carbonate catalyzed efficient synthesis of quinazoline-2,4(1H,3H)-diones using carbon dioxide and 2-aminobenzonitriles