Payal Tiwari

TL;DR: Results indicate that ovarian cancer cells reprogram fibroblasts to become CAFs through the action of miRNAs, which may represent novel therapeutic targets in the tumor microenvironment.

TL;DR: It is suggested that fibronectin promotes ovarian cancer invasion and metastasis through an α5β1-integrin/c-Met/FAK/Src-dependent signaling pathway, transducing signals through c-Met in an HGF/SF-independent manner.

TL;DR: It is demonstrated that mitochondrial metabolism can be exploited by targeting BACH1 to sensitize breast cancer and potentially other tumour tissues to mitochondrial inhibitors.

TL;DR: This paper showed that obesity reprograms mammary adipose tissue macrophages to a pro-inflammatory metabolically activated phenotype (MMe) that alters the niche to support tumor formation.

TL;DR: In this paper, the role of microenvironmental cues in the regulation of miRNAs in metastasizing cancer cells has been studied using a three-dimensional culture model that mimics the human omentum, one of the principal sites of ovarian cancer metastasis.