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Pedro D'Orléans-Juste
Researcher at Université de Sherbrooke
Publications - 228
Citations - 7295
Pedro D'Orléans-Juste is an academic researcher from Université de Sherbrooke. The author has contributed to research in topics: Receptor & Endothelin receptor. The author has an hindex of 45, co-authored 225 publications receiving 7079 citations. Previous affiliations of Pedro D'Orléans-Juste include University of Ferrara & Faculté de médecine – Université de Sherbrooke.
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Journal ArticleDOI
Growth regulatory properties of endothelins
TL;DR: Evidence now suggests that the three isoforms of endothelins (ET-1 and the other two related isopeptides, ET-2 and ET-3) regulate growth in several of these cells, suggesting an important role mediating vascular remodeling in some cardiovascular diseases.
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Pharmacological receptors for substance P and neurokinins.
TL;DR: A neurokinin receptor classification is attempted using the neurokinins and their fragments to determine the order of potency of agonists and some potent compounds have been identified that could provide selective receptor ligands.
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Selective agonists for substance P and neurokinin receptors.
TL;DR: The results of the present study indicate that a) [Sar9,Met(O2)11]SP is a potent and selective agonist for the NK-P receptors of the dog carotid artery; b) [MePhe7]NKB is a very powerful and selective stimulant of receptors for neurokinin B and c) [Nle10]NKA (4-10) is a promising compound, showing some selectivity for NK-A receptor.
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Effects of peptides and non-peptides on isolated arterial smooth muscles: Role of endothelium
TL;DR: It is suggested that the site of action of several vasodilators is the endothelium, while other vasodILators and all the vasoconstrictors influence the arterial vessels tone presumably by acting on the smooth muscle cells.
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Characterization of neurokinin receptors in various isolated organs by the use of selective agonists.
S. Dion,Pedro D'Orléans-Juste,Guy Drapeau,Nour Eddine Rhaleb,N. Rouissi,C. Tousignant,Domenico Regoli +6 more
TL;DR: Previous observations that the dog carotid artery, the rabbit pulmonary artery and the rat portal vein are selective preparations respectively for SP, NKA and NKB were confirmed in the present study by showing that only the respective selective agonists were active on these tissues.